Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient
Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant p...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2017/5121032 |
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| _version_ | 1850167843720527872 |
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| author | Alicia M. Teagarden Brian D. Leland Courtney M. Rowan Riad Lutfi |
| author_facet | Alicia M. Teagarden Brian D. Leland Courtney M. Rowan Riad Lutfi |
| author_sort | Alicia M. Teagarden |
| collection | DOAJ |
| description | Thiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, who developed profound lactic acidosis of unknown etiology. After countless evaluations for likely causes, the patient was ultimately determined to have thiamine deficiency and her acidosis resolved rapidly with vitamin supplementation. |
| format | Article |
| id | doaj-art-dfeec74c86a247e9b8801231c12b55fa |
| institution | OA Journals |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-dfeec74c86a247e9b8801231c12b55fa2025-08-20T02:21:07ZengWileyCase Reports in Critical Care2090-64202090-64392017-01-01201710.1155/2017/51210325121032Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric PatientAlicia M. Teagarden0Brian D. Leland1Courtney M. Rowan2Riad Lutfi3Section of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USASection of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USASection of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USASection of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USAThiamine plays a critical role in energy metabolism. Critically ill children and adults may develop thiamine deficiency with ultimately increased mortality due to potentially irreversible consequences of severe type B lactic acidosis. We report a case of an unvaccinated term neonate with malignant pertussis requiring extracorporeal membrane oxygenation and continuous renal replacement therapy, who developed profound lactic acidosis of unknown etiology. After countless evaluations for likely causes, the patient was ultimately determined to have thiamine deficiency and her acidosis resolved rapidly with vitamin supplementation.http://dx.doi.org/10.1155/2017/5121032 |
| spellingShingle | Alicia M. Teagarden Brian D. Leland Courtney M. Rowan Riad Lutfi Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient Case Reports in Critical Care |
| title | Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient |
| title_full | Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient |
| title_fullStr | Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient |
| title_full_unstemmed | Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient |
| title_short | Thiamine Deficiency Leading to Refractory Lactic Acidosis in a Pediatric Patient |
| title_sort | thiamine deficiency leading to refractory lactic acidosis in a pediatric patient |
| url | http://dx.doi.org/10.1155/2017/5121032 |
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