Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study
(1) Background: The aim of this prospective study was to evaluate the efficacy of topical application of leukocyte- and platelet-rich fibrin (L-PRF) membranes for treating chronic cutaneous wounds in dogs. (2) Methods: Chronic wounds unresponsive to conventional treatments were assessed on digital p...
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2025-01-01
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| author | Federica Aragosa Gerardo Fatone Chiara Caterino Stefano Cavalli Alfonso Piscitelli Rosario Vallefuoco Francesco Lamagna Giovanni Della Valle |
| author_facet | Federica Aragosa Gerardo Fatone Chiara Caterino Stefano Cavalli Alfonso Piscitelli Rosario Vallefuoco Francesco Lamagna Giovanni Della Valle |
| author_sort | Federica Aragosa |
| collection | DOAJ |
| description | (1) Background: The aim of this prospective study was to evaluate the efficacy of topical application of leukocyte- and platelet-rich fibrin (L-PRF) membranes for treating chronic cutaneous wounds in dogs. (2) Methods: Chronic wounds unresponsive to conventional treatments were assessed on digital photographs and classified using the Bates-Jensen Wound Assessment Tool (BWAT). Each lesion was treated with L-PRF membranes. Epithelialization, granulation tissue formation, wound healing rate, and contraction were statistically analyzed during follow-up. (3) Results: All but one of the cases were treated with a single application of L-PRF for a median of 30 days after onset. All wounds healed after a median of 22 days. The BWAT score, total wound area, and granulation tissue decreased significantly over time while wound contraction increased. The most significant reduction in the total wound area was observed within the first 3 weeks after treatment. None of the dogs required the administration of antibiotics. (4) Conclusions: L-PRF membrane promoted the wound healing process in dogs and is a valuable and cost-effective tool for treating chronic wounds, thereby reducing the need for antibiotics administration. |
| format | Article |
| id | doaj-art-dfe904eaf7d1491e97232547b6eaded4 |
| institution | Kabale University |
| issn | 2076-2615 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-dfe904eaf7d1491e97232547b6eaded42025-01-10T13:14:06ZengMDPI AGAnimals2076-26152025-01-0115111210.3390/ani15010112Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective StudyFederica Aragosa0Gerardo Fatone1Chiara Caterino2Stefano Cavalli3Alfonso Piscitelli4Rosario Vallefuoco5Francesco Lamagna6Giovanni Della Valle7Department of Veterinary Medicine and Animal Production, University of Naples “Federico II”, 80137 Naples, ItalyDepartment of Veterinary Medicine and Animal Production, University of Naples “Federico II”, 80137 Naples, ItalyDepartment of Veterinary Medicine and Animal Production, University of Naples “Federico II”, 80137 Naples, ItalyDepartment of Veterinary Medicine and Animal Production, University of Naples “Federico II”, 80137 Naples, ItalyDepartment of Agricultural Sciences, University of Naples “Federico II”, 80055 Portici, ItalyPride Veterinary Referrals, Derby DE24 8HX, UKDepartment of Veterinary Medicine and Animal Production, University of Naples “Federico II”, 80137 Naples, ItalyDepartment of Veterinary Medicine and Animal Production, University of Naples “Federico II”, 80137 Naples, Italy(1) Background: The aim of this prospective study was to evaluate the efficacy of topical application of leukocyte- and platelet-rich fibrin (L-PRF) membranes for treating chronic cutaneous wounds in dogs. (2) Methods: Chronic wounds unresponsive to conventional treatments were assessed on digital photographs and classified using the Bates-Jensen Wound Assessment Tool (BWAT). Each lesion was treated with L-PRF membranes. Epithelialization, granulation tissue formation, wound healing rate, and contraction were statistically analyzed during follow-up. (3) Results: All but one of the cases were treated with a single application of L-PRF for a median of 30 days after onset. All wounds healed after a median of 22 days. The BWAT score, total wound area, and granulation tissue decreased significantly over time while wound contraction increased. The most significant reduction in the total wound area was observed within the first 3 weeks after treatment. None of the dogs required the administration of antibiotics. (4) Conclusions: L-PRF membrane promoted the wound healing process in dogs and is a valuable and cost-effective tool for treating chronic wounds, thereby reducing the need for antibiotics administration.https://www.mdpi.com/2076-2615/15/1/112platelet concentratesL-PRFsecond intentionspontaneous woundsregenerative medicine |
| spellingShingle | Federica Aragosa Gerardo Fatone Chiara Caterino Stefano Cavalli Alfonso Piscitelli Rosario Vallefuoco Francesco Lamagna Giovanni Della Valle Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study Animals platelet concentrates L-PRF second intention spontaneous wounds regenerative medicine |
| title | Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study |
| title_full | Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study |
| title_fullStr | Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study |
| title_full_unstemmed | Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study |
| title_short | Evaluation of the Effects of Autologous Leukocyte- and Platelet-Rich Fibrin Membranes for Treating Chronic Wounds: A Prospective Study |
| title_sort | evaluation of the effects of autologous leukocyte and platelet rich fibrin membranes for treating chronic wounds a prospective study |
| topic | platelet concentrates L-PRF second intention spontaneous wounds regenerative medicine |
| url | https://www.mdpi.com/2076-2615/15/1/112 |
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