Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study
Abstract Introduction The potential teratogenic risk of traditional Chinese medicine (TCM) is of widespread concern; however, related evidence is largely absent in humans. This study aimed to compare the prevalence of congenital malformations between pregnant women with and without TCM exposure. Mat...
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Wiley
2023-06-01
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| Series: | Acta Obstetricia et Gynecologica Scandinavica |
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| Online Access: | https://doi.org/10.1111/aogs.14553 |
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| author | Ting Peng Lin‐Liang Yin Yu Xiong Feng Xie Chun‐Ya Ji Zhong Yang Qi Pan Ming‐Qing Li Xue‐Dong Deng Jing Dong Jiang‐Nan Wu |
| author_facet | Ting Peng Lin‐Liang Yin Yu Xiong Feng Xie Chun‐Ya Ji Zhong Yang Qi Pan Ming‐Qing Li Xue‐Dong Deng Jing Dong Jiang‐Nan Wu |
| author_sort | Ting Peng |
| collection | DOAJ |
| description | Abstract Introduction The potential teratogenic risk of traditional Chinese medicine (TCM) is of widespread concern; however, related evidence is largely absent in humans. This study aimed to compare the prevalence of congenital malformations between pregnant women with and without TCM exposure. Material and methods This was a multicenter prospective cohort study of 17 713 women who participated in a survey on periconceptional TCM exposure. Primary outcome was congenital malformations diagnosed from a survey conducted on the day 42 after delivery. Results A total of 16 751 pregnant women with 273 congenital malformations were included in the analysis. Fetuses exposed to TCM had an increased risk of congenital malformations compared to those without exposure (odds ratio [OR] 2.10; 95% confidence interval [CI] 1.09–4.02) after controlling for potential confounders. There were significant associations with congenital malformations in women with early pregnant exposure (OR 2.04, 95% CI 1.00–4.20) and for those who received ≥2 TCM formulas (OR 5.84, 95% CI 1.44–23.65). Pre‐pregnancy TCM exposure was significantly associated with an increased risk of congenital heart defects (OR 12.69; 95% CI 3.01–53.51). Conclusions Periconceptional TCM exposure is associated with an increased risk of congenital malformation. This effect was cumulative and sensitive to periconceptional age. Therefore, TCM deserves more attention and should be used cautiously for pregnant women and those trying to become pregnant. |
| format | Article |
| id | doaj-art-dfe021c4cbc346088da1ea3005442513 |
| institution | OA Journals |
| issn | 0001-6349 1600-0412 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Acta Obstetricia et Gynecologica Scandinavica |
| spelling | doaj-art-dfe021c4cbc346088da1ea30054425132025-08-20T02:09:34ZengWileyActa Obstetricia et Gynecologica Scandinavica0001-63491600-04122023-06-01102673574310.1111/aogs.14553Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort studyTing Peng0Lin‐Liang Yin1Yu Xiong2Feng Xie3Chun‐Ya Ji4Zhong Yang5Qi Pan6Ming‐Qing Li7Xue‐Dong Deng8Jing Dong9Jiang‐Nan Wu10Department of Obstetrics, Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaCenter for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital Suzhou ChinaDepartment of Obstetrics, Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaMedical Center of Diagnosis and Treatment for Cervical Disease Obstetrics and Gynecology Hospital of Fudan University Shanghai ChinaCenter for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital Suzhou ChinaCenter for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital Suzhou ChinaCenter for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital Suzhou ChinaDepartment of Obstetrics, Obstetrics and Gynecology Hospital Fudan University Shanghai ChinaCenter for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital Suzhou ChinaMedical Center of Diagnosis and Treatment for Cervical Disease Obstetrics and Gynecology Hospital of Fudan University Shanghai ChinaShanghai Key Laboratory of Female Reproductive Endocrine‐Related Diseases Shanghai ChinaAbstract Introduction The potential teratogenic risk of traditional Chinese medicine (TCM) is of widespread concern; however, related evidence is largely absent in humans. This study aimed to compare the prevalence of congenital malformations between pregnant women with and without TCM exposure. Material and methods This was a multicenter prospective cohort study of 17 713 women who participated in a survey on periconceptional TCM exposure. Primary outcome was congenital malformations diagnosed from a survey conducted on the day 42 after delivery. Results A total of 16 751 pregnant women with 273 congenital malformations were included in the analysis. Fetuses exposed to TCM had an increased risk of congenital malformations compared to those without exposure (odds ratio [OR] 2.10; 95% confidence interval [CI] 1.09–4.02) after controlling for potential confounders. There were significant associations with congenital malformations in women with early pregnant exposure (OR 2.04, 95% CI 1.00–4.20) and for those who received ≥2 TCM formulas (OR 5.84, 95% CI 1.44–23.65). Pre‐pregnancy TCM exposure was significantly associated with an increased risk of congenital heart defects (OR 12.69; 95% CI 3.01–53.51). Conclusions Periconceptional TCM exposure is associated with an increased risk of congenital malformation. This effect was cumulative and sensitive to periconceptional age. Therefore, TCM deserves more attention and should be used cautiously for pregnant women and those trying to become pregnant.https://doi.org/10.1111/aogs.14553cohort studycongenital heart defectscongenital malformationsSpatholobi caulisSpatholobus suberectustraditional Chinese medicine |
| spellingShingle | Ting Peng Lin‐Liang Yin Yu Xiong Feng Xie Chun‐Ya Ji Zhong Yang Qi Pan Ming‐Qing Li Xue‐Dong Deng Jing Dong Jiang‐Nan Wu Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study Acta Obstetricia et Gynecologica Scandinavica cohort study congenital heart defects congenital malformations Spatholobi caulis Spatholobus suberectus traditional Chinese medicine |
| title | Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study |
| title_full | Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study |
| title_fullStr | Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study |
| title_full_unstemmed | Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study |
| title_short | Retracted: Maternal traditional Chinese medicine exposure and risk of congenital malformations: a multicenter prospective cohort study |
| title_sort | retracted maternal traditional chinese medicine exposure and risk of congenital malformations a multicenter prospective cohort study |
| topic | cohort study congenital heart defects congenital malformations Spatholobi caulis Spatholobus suberectus traditional Chinese medicine |
| url | https://doi.org/10.1111/aogs.14553 |
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