Analysis of genomic heterogeneity and the mutational landscape in cutaneous squamous cell carcinoma through multi-patient-targeted single-cell DNA sequencing

Analysis of genomic heterogeneity and the mutational landscape in cutaneous squamous cell carcinoma through multi-patient-targeted single-cell DNA sequencing

Abstract Background Cutaneous squamous cell carcinoma (CSCC) is a prevalent skin cancer with aggressive progression that poses significant challenges, especially in metastatic cases. Single-cell DNA sequencing (scDNA-seq) has become an advanced technology for elucidating tumor heterogeneity and clon...

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Bibliographic Details
Main Authors: Wen Chen, Jiawei Xu, Chengdong Yu, Meng Zhou, Yong Ai, Wenbing Rao, Qingchuan Wang, Siyi Xu, Lei Tang, Si Gong, Jun Rao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Cancer
Subjects:
Cutaneous squamous cell carcinoma (CSCC)
Genomic heterogeneity
Mutational landscape
Evolutionary dynamics
Online Access:https://doi.org/10.1186/s12885-025-14585-z
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