Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer
This study aimed to investigate cytological abnormalities indicative of chromosome damage (micronuclei) and apoptosis (karyorrhexis, pyknosis, and condensed chromatin) in exfoliated cells from the buccal mucosa of patients with oral cancer and control subjects. The sample included twenty individuals...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2012/457054 |
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| _version_ | 1849467686500696064 |
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| author | Lavínia Tércia Magalhães Dórea José Roberto Cardoso Meireles Júlia Paula Ramos Lessa Márcio Campos Oliveira Carlos Alberto de Bragança Pereira Adriano Polpo de Campos Eneida de Moraes Macílio Cerqueira |
| author_facet | Lavínia Tércia Magalhães Dórea José Roberto Cardoso Meireles Júlia Paula Ramos Lessa Márcio Campos Oliveira Carlos Alberto de Bragança Pereira Adriano Polpo de Campos Eneida de Moraes Macílio Cerqueira |
| author_sort | Lavínia Tércia Magalhães Dórea |
| collection | DOAJ |
| description | This study aimed to investigate cytological abnormalities indicative of chromosome damage (micronuclei) and apoptosis (karyorrhexis, pyknosis, and condensed chromatin) in exfoliated cells from the buccal mucosa of patients with oral cancer and control subjects. The sample included twenty individuals with oral cancer and forty individuals with normal buccal mucosa. Material was collected from the cheek epithelium in areas with lesions and areas without abnormalities. A minimum of one thousand cells was analyzed. Micronuclei were found significantly more frequently in cells collected from lesions than in cells from normal areas, independent of the presence/absence of cancer (P<0.0001). They were also significantly more frequent in smokers and in mouthwash users (P<0.0001). Apoptosis occurred significantly less frequently in individuals with oral cancer (P<0.0001). These results show that oral cancer is associated with higher frequency of chromosomal damage and suggest that apoptosis is compromised in the buccal cells of individuals with this kind of neoplasia. |
| format | Article |
| id | doaj-art-dfd31c23a64b42a2934ad28d4d316ac6 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-dfd31c23a64b42a2934ad28d4d316ac62025-08-20T03:26:09ZengWileyInternational Journal of Dentistry1687-87281687-87362012-01-01201210.1155/2012/457054457054Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral CancerLavínia Tércia Magalhães Dórea0José Roberto Cardoso Meireles1Júlia Paula Ramos Lessa2Márcio Campos Oliveira3Carlos Alberto de Bragança Pereira4Adriano Polpo de Campos5Eneida de Moraes Macílio Cerqueira6Laboratory of Toxicological Genetics, Department of Biological Science, Feira de Santana State University, Avendia Transnordestina s/n, 44.036-900 Feira de Santana, BA, BrazilLaboratory of Toxicological Genetics, Department of Biological Science, Feira de Santana State University, Avendia Transnordestina s/n, 44.036-900 Feira de Santana, BA, BrazilLaboratory of Toxicological Genetics, Department of Biological Science, Feira de Santana State University, Avendia Transnordestina s/n, 44.036-900 Feira de Santana, BA, BrazilBuccal Pathology Laboratory, Department of Health, Feira de Santana State University, Avendia Transnordestina s/n, 44.036-900 Feira de Santana, BA, BrazilDepartment of Mathematics and Statistics, São Paulo State University, Rua do Mãtao 1010, 05508-090 São Paulo, SP, BrazilDepartment of Statistics, São Carlos Federal University, Via Washington Luis Km 235, 13565-905 São Carlos, SP, BrazilLaboratory of Toxicological Genetics, Department of Biological Science, Feira de Santana State University, Avendia Transnordestina s/n, 44.036-900 Feira de Santana, BA, BrazilThis study aimed to investigate cytological abnormalities indicative of chromosome damage (micronuclei) and apoptosis (karyorrhexis, pyknosis, and condensed chromatin) in exfoliated cells from the buccal mucosa of patients with oral cancer and control subjects. The sample included twenty individuals with oral cancer and forty individuals with normal buccal mucosa. Material was collected from the cheek epithelium in areas with lesions and areas without abnormalities. A minimum of one thousand cells was analyzed. Micronuclei were found significantly more frequently in cells collected from lesions than in cells from normal areas, independent of the presence/absence of cancer (P<0.0001). They were also significantly more frequent in smokers and in mouthwash users (P<0.0001). Apoptosis occurred significantly less frequently in individuals with oral cancer (P<0.0001). These results show that oral cancer is associated with higher frequency of chromosomal damage and suggest that apoptosis is compromised in the buccal cells of individuals with this kind of neoplasia.http://dx.doi.org/10.1155/2012/457054 |
| spellingShingle | Lavínia Tércia Magalhães Dórea José Roberto Cardoso Meireles Júlia Paula Ramos Lessa Márcio Campos Oliveira Carlos Alberto de Bragança Pereira Adriano Polpo de Campos Eneida de Moraes Macílio Cerqueira Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer International Journal of Dentistry |
| title | Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer |
| title_full | Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer |
| title_fullStr | Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer |
| title_full_unstemmed | Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer |
| title_short | Chromosomal Damage and Apoptosis in Exfoliated Buccal Cells from Individuals with Oral Cancer |
| title_sort | chromosomal damage and apoptosis in exfoliated buccal cells from individuals with oral cancer |
| url | http://dx.doi.org/10.1155/2012/457054 |
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