Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity.
<h4>Objective</h4>To establish normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in southern Thai women, and to compare these reference levels with Caucasian-specific and northern Thai models.<h4>Methods</h4>A...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182538&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850230037156986880 |
|---|---|
| author | Ounjai Kor-Anantakul Thitima Suntharasaj Chitkasaem Suwanrath Tharangrut Hanprasertpong Savitree Pranpanus Ninlapa Pruksanusak Suthiraporn Janwadee Alan Geater |
| author_facet | Ounjai Kor-Anantakul Thitima Suntharasaj Chitkasaem Suwanrath Tharangrut Hanprasertpong Savitree Pranpanus Ninlapa Pruksanusak Suthiraporn Janwadee Alan Geater |
| author_sort | Ounjai Kor-Anantakul |
| collection | DOAJ |
| description | <h4>Objective</h4>To establish normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in southern Thai women, and to compare these reference levels with Caucasian-specific and northern Thai models.<h4>Methods</h4>A cross-sectional study was conducted in 1,150 normal singleton pregnancy women to determine serum pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (β-hCG) concentrations in women from southern Thailand. The predicted median values were compared with published equations for Caucasians and northern Thai women.<h4>Results</h4>The best-fitting regression equations for the expected median serum levels of PAPP-A (mIU/L) and free β- hCG (ng/mL) according to maternal weight (Wt in kg) and gestational age (GA in days) were: [Formula: see text] and [Formula: see text] Both equations were selected with a statistically significant contribution (p< 0.05). Compared with the Caucasian model, the median values of PAPP-A were higher and the median values of free β-hCG were lower in the southern Thai women. And compared with the northern Thai models, the median values of both biomarkers were lower in southern Thai women.<h4>Conclusion</h4>The study has successfully developed maternal-weight- and gestational-age-adjusted median normative models to convert the PAPP-A and free β-hCG levels into their Multiple of Median equivalents in southern Thai women. These models confirmed ethnic differences. |
| format | Article |
| id | doaj-art-dfd2f7de439b4305a55e4f858274e0e6 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-dfd2f7de439b4305a55e4f858274e0e62025-08-20T02:03:59ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018253810.1371/journal.pone.0182538Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity.Ounjai Kor-AnantakulThitima SuntharasajChitkasaem SuwanrathTharangrut HanprasertpongSavitree PranpanusNinlapa PruksanusakSuthiraporn JanwadeeAlan Geater<h4>Objective</h4>To establish normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in southern Thai women, and to compare these reference levels with Caucasian-specific and northern Thai models.<h4>Methods</h4>A cross-sectional study was conducted in 1,150 normal singleton pregnancy women to determine serum pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin (β-hCG) concentrations in women from southern Thailand. The predicted median values were compared with published equations for Caucasians and northern Thai women.<h4>Results</h4>The best-fitting regression equations for the expected median serum levels of PAPP-A (mIU/L) and free β- hCG (ng/mL) according to maternal weight (Wt in kg) and gestational age (GA in days) were: [Formula: see text] and [Formula: see text] Both equations were selected with a statistically significant contribution (p< 0.05). Compared with the Caucasian model, the median values of PAPP-A were higher and the median values of free β-hCG were lower in the southern Thai women. And compared with the northern Thai models, the median values of both biomarkers were lower in southern Thai women.<h4>Conclusion</h4>The study has successfully developed maternal-weight- and gestational-age-adjusted median normative models to convert the PAPP-A and free β-hCG levels into their Multiple of Median equivalents in southern Thai women. These models confirmed ethnic differences.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182538&type=printable |
| spellingShingle | Ounjai Kor-Anantakul Thitima Suntharasaj Chitkasaem Suwanrath Tharangrut Hanprasertpong Savitree Pranpanus Ninlapa Pruksanusak Suthiraporn Janwadee Alan Geater Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity. PLoS ONE |
| title | Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity. |
| title_full | Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity. |
| title_fullStr | Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity. |
| title_full_unstemmed | Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity. |
| title_short | Normative weight-adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity. |
| title_sort | normative weight adjusted models for the median levels of first trimester serum biomarkers for trisomy 21 screening in a specific ethnicity |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0182538&type=printable |
| work_keys_str_mv | AT ounjaikoranantakul normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity AT thitimasuntharasaj normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity AT chitkasaemsuwanrath normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity AT tharangruthanprasertpong normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity AT savitreepranpanus normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity AT ninlapapruksanusak normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity AT suthirapornjanwadee normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity AT alangeater normativeweightadjustedmodelsforthemedianlevelsoffirsttrimesterserumbiomarkersfortrisomy21screeninginaspecificethnicity |