Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency Department
Objective: We aimed to compare the effectiveness of systemic oral ivermectin and topical permethrin in the treatment of scabies in emergency departments (ED). Materials and Methods: In this prospective, observational, cross-sectional single-center study, patients who presented to the ED with prurit...
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| Format: | Article |
| Language: | English |
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Türkiye Acil Tıp Vakfı
2025-04-01
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| Series: | Global Emergency and Critical Care |
| Subjects: | |
| Online Access: | https://globemcc.com/articles/comparative-effectiveness-of-ivermectin-and-permethrin-in-the-treatment-of-scabies-diagnosed-in-the-emergency-department/doi/globecc.galenos.2024.99609 |
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| author | Tuba Betül Ümit Hüseyin Ergenç Halil Altınmaden |
| author_facet | Tuba Betül Ümit Hüseyin Ergenç Halil Altınmaden |
| author_sort | Tuba Betül Ümit |
| collection | DOAJ |
| description | Objective: We aimed to compare the effectiveness of systemic oral ivermectin and topical permethrin in the treatment of scabies in emergency departments (ED).
Materials and Methods: In this prospective, observational, cross-sectional single-center study, patients who presented to the ED with pruritus and were diagnosed with scabies received either topical permethrin or oral ivermectin, based on the clinician’s preference. After treatment, the patients were scheduled for follow-up examinations one and two weeks later to assess the treatment effectiveness.
Results: A total of 177 patients were included in this study, comprising 106 (59.9%) men and 71 (40.1%) women. No statistically significant difference was found in terms of treatment effectiveness between patients using topical permethrin and those using oral ivermectin at the 7- and 14-day follow-ups (p=0.656 and p=0.604, respectively). After two courses of treatment, 42 (23.7%) patients were considered to have an ineffective response and received alternative treatment.
Conclusion: Scabies are managed and treated by dermatologists and emergency medicine physicians in Türkiye. The effectiveness of topical permethrin and oral ivermectin, which are commonly used as first-line treatments for scabies, appears to be similar. The treatment efficacies of both drugs were lower than expected. Improvements in patient adherence and medication access, family member contributions to treatment, and patient education regarding home hygiene can improve treatment outcomes. |
| format | Article |
| id | doaj-art-dfd03a87a69d407a8e327336741b8440 |
| institution | Kabale University |
| issn | 2822-4078 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Türkiye Acil Tıp Vakfı |
| record_format | Article |
| series | Global Emergency and Critical Care |
| spelling | doaj-art-dfd03a87a69d407a8e327336741b84402025-08-20T03:52:11ZengTürkiye Acil Tıp VakfıGlobal Emergency and Critical Care2822-40782025-04-0141353810.4274/globecc.galenos.2024.99609Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency DepartmentTuba Betül Ümit0https://orcid.org/0000-0001-9852-3034Hüseyin Ergenç1https://orcid.org/0000-0002-1325-3360Halil Altınmaden2https://orcid.org/0000-0002-9928-1388University of Health Sciences Türkiye Haseki Training and Research Hospital, Clinic of Emergency Medicine, İstanbul, TürkiyeUniversity of Health Sciences Türkiye Haseki Training and Research Hospital, Clinic of Emergency Medicine, İstanbul, TürkiyeUniversity of Health Sciences Türkiye Haseki Training and Research Hospital, Clinic of Emergency Medicine, İstanbul, TürkiyeObjective: We aimed to compare the effectiveness of systemic oral ivermectin and topical permethrin in the treatment of scabies in emergency departments (ED). Materials and Methods: In this prospective, observational, cross-sectional single-center study, patients who presented to the ED with pruritus and were diagnosed with scabies received either topical permethrin or oral ivermectin, based on the clinician’s preference. After treatment, the patients were scheduled for follow-up examinations one and two weeks later to assess the treatment effectiveness. Results: A total of 177 patients were included in this study, comprising 106 (59.9%) men and 71 (40.1%) women. No statistically significant difference was found in terms of treatment effectiveness between patients using topical permethrin and those using oral ivermectin at the 7- and 14-day follow-ups (p=0.656 and p=0.604, respectively). After two courses of treatment, 42 (23.7%) patients were considered to have an ineffective response and received alternative treatment. Conclusion: Scabies are managed and treated by dermatologists and emergency medicine physicians in Türkiye. The effectiveness of topical permethrin and oral ivermectin, which are commonly used as first-line treatments for scabies, appears to be similar. The treatment efficacies of both drugs were lower than expected. Improvements in patient adherence and medication access, family member contributions to treatment, and patient education regarding home hygiene can improve treatment outcomes.https://globemcc.com/articles/comparative-effectiveness-of-ivermectin-and-permethrin-in-the-treatment-of-scabies-diagnosed-in-the-emergency-department/doi/globecc.galenos.2024.99609scabiesitchingsarcoptes scabieipruritus |
| spellingShingle | Tuba Betül Ümit Hüseyin Ergenç Halil Altınmaden Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency Department Global Emergency and Critical Care scabies itching sarcoptes scabiei pruritus |
| title | Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency Department |
| title_full | Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency Department |
| title_fullStr | Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency Department |
| title_full_unstemmed | Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency Department |
| title_short | Comparative Effectiveness of Ivermectin and Permethrin in the Treatment of Scabies Diagnosed in the Emergency Department |
| title_sort | comparative effectiveness of ivermectin and permethrin in the treatment of scabies diagnosed in the emergency department |
| topic | scabies itching sarcoptes scabiei pruritus |
| url | https://globemcc.com/articles/comparative-effectiveness-of-ivermectin-and-permethrin-in-the-treatment-of-scabies-diagnosed-in-the-emergency-department/doi/globecc.galenos.2024.99609 |
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