Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor Therapy

BACKGROUND: Proton pump inhibitors (PPIs) are the most potent drugs available for the management of gastroesophageal reflux disease (GERD). Ambulatory 24 h pH monitoring is often recommended for patients experiencing symptoms despite PPI therapy. Recent pivotal data suggest that pH studies are predi...

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Main Authors: Barbara A MacKalski, Alexandra Ilnyckyj
Format: Article
Language:English
Published: Wiley 2008-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2008/862302
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author Barbara A MacKalski
Alexandra Ilnyckyj
author_facet Barbara A MacKalski
Alexandra Ilnyckyj
author_sort Barbara A MacKalski
collection DOAJ
description BACKGROUND: Proton pump inhibitors (PPIs) are the most potent drugs available for the management of gastroesophageal reflux disease (GERD). Ambulatory 24 h pH monitoring is often recommended for patients experiencing symptoms despite PPI therapy. Recent pivotal data suggest that pH studies are predictably normal in this setting, casting doubt on the clinical utility of the current practice.
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spelling doaj-art-dfcd3a26247a4bb69a98781d128cc45a2025-02-03T01:27:17ZengWileyCanadian Journal of Gastroenterology0835-79002008-01-0122324925210.1155/2008/862302Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor TherapyBarbara A MacKalski0Alexandra Ilnyckyj1Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, CanadaSection of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, CanadaBACKGROUND: Proton pump inhibitors (PPIs) are the most potent drugs available for the management of gastroesophageal reflux disease (GERD). Ambulatory 24 h pH monitoring is often recommended for patients experiencing symptoms despite PPI therapy. Recent pivotal data suggest that pH studies are predictably normal in this setting, casting doubt on the clinical utility of the current practice.http://dx.doi.org/10.1155/2008/862302
spellingShingle Barbara A MacKalski
Alexandra Ilnyckyj
Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor Therapy
Canadian Journal of Gastroenterology
title Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor Therapy
title_full Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor Therapy
title_fullStr Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor Therapy
title_full_unstemmed Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor Therapy
title_short Esophageal pH Testing in Patients Refractory to Proton Pump Inhibitor Therapy
title_sort esophageal ph testing in patients refractory to proton pump inhibitor therapy
url http://dx.doi.org/10.1155/2008/862302
work_keys_str_mv AT barbaraamackalski esophagealphtestinginpatientsrefractorytoprotonpumpinhibitortherapy
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