Engineering and targeting potential of CAR NK cells in colorectal cancer
Abstract. Colorectal cancer (CRC), a major global health concern, necessitates innovative treatments. Chimeric antigen receptor (CAR) T cells have shown promises, yet they grapple with challenges. The spotlight pivots to the rising heroes: CAR natural killer (NK) cells, offering advantages such as h...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer
2025-07-01
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| Series: | Chinese Medical Journal |
| Online Access: | http://journals.lww.com/10.1097/CM9.0000000000003346 |
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| _version_ | 1849418575919448064 |
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| author | Muhammad Babar Khawar Ali Afzal Shuangshuang Dong Yue Si Haibo Sun Yuanyuan Ji |
| author_facet | Muhammad Babar Khawar Ali Afzal Shuangshuang Dong Yue Si Haibo Sun Yuanyuan Ji |
| author_sort | Muhammad Babar Khawar |
| collection | DOAJ |
| description | Abstract. Colorectal cancer (CRC), a major global health concern, necessitates innovative treatments. Chimeric antigen receptor (CAR) T cells have shown promises, yet they grapple with challenges. The spotlight pivots to the rising heroes: CAR natural killer (NK) cells, offering advantages such as higher safety profiles, cost-effectiveness, and efficacy against solid tumors. Nevertheless, the specific mechanisms underlying CAR NK cell trafficking and their interplay within the complex tumor microenvironment require further in-depth exploration. Herein, we provide insights into the design and engineering of CAR NK cells, antigen targets in CRC, and success in overcoming resistance mechanisms with an emphasis on the potential for clinical trials. |
| format | Article |
| id | doaj-art-dfcce6e8180847fea208264d17d33e30 |
| institution | Kabale University |
| issn | 0366-6999 2542-5641 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Chinese Medical Journal |
| spelling | doaj-art-dfcce6e8180847fea208264d17d33e302025-08-20T03:32:24ZengWolters KluwerChinese Medical Journal0366-69992542-56412025-07-01138131529153910.1097/CM9.0000000000003346202507050-00006Engineering and targeting potential of CAR NK cells in colorectal cancerMuhammad Babar Khawar0Ali Afzal1Shuangshuang Dong2Yue Si3Haibo Sun4Yuanyuan Ji1 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China1 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China1 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China1 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, China1 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225009, ChinaAbstract. Colorectal cancer (CRC), a major global health concern, necessitates innovative treatments. Chimeric antigen receptor (CAR) T cells have shown promises, yet they grapple with challenges. The spotlight pivots to the rising heroes: CAR natural killer (NK) cells, offering advantages such as higher safety profiles, cost-effectiveness, and efficacy against solid tumors. Nevertheless, the specific mechanisms underlying CAR NK cell trafficking and their interplay within the complex tumor microenvironment require further in-depth exploration. Herein, we provide insights into the design and engineering of CAR NK cells, antigen targets in CRC, and success in overcoming resistance mechanisms with an emphasis on the potential for clinical trials.http://journals.lww.com/10.1097/CM9.0000000000003346 |
| spellingShingle | Muhammad Babar Khawar Ali Afzal Shuangshuang Dong Yue Si Haibo Sun Yuanyuan Ji Engineering and targeting potential of CAR NK cells in colorectal cancer Chinese Medical Journal |
| title | Engineering and targeting potential of CAR NK cells in colorectal cancer |
| title_full | Engineering and targeting potential of CAR NK cells in colorectal cancer |
| title_fullStr | Engineering and targeting potential of CAR NK cells in colorectal cancer |
| title_full_unstemmed | Engineering and targeting potential of CAR NK cells in colorectal cancer |
| title_short | Engineering and targeting potential of CAR NK cells in colorectal cancer |
| title_sort | engineering and targeting potential of car nk cells in colorectal cancer |
| url | http://journals.lww.com/10.1097/CM9.0000000000003346 |
| work_keys_str_mv | AT muhammadbabarkhawar engineeringandtargetingpotentialofcarnkcellsincolorectalcancer AT aliafzal engineeringandtargetingpotentialofcarnkcellsincolorectalcancer AT shuangshuangdong engineeringandtargetingpotentialofcarnkcellsincolorectalcancer AT yuesi engineeringandtargetingpotentialofcarnkcellsincolorectalcancer AT haibosun engineeringandtargetingpotentialofcarnkcellsincolorectalcancer AT yuanyuanji engineeringandtargetingpotentialofcarnkcellsincolorectalcancer |