Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive Disorder
Background: The recurring actions and intrusive thoughts that characterise obsessive–compulsive disorder (OCD), a long-term mental illness, are known as compulsions. The cornerstones of conventional treatment are psychological counselling and prescribed medication; nonetheless, interest in complemen...
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MDPI AG
2024-12-01
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| author | Veerabhadrappa Pallavi Sathvika Prathibha Guttal Subhas Debayan Bhattacharjee Vejetha Nagaraj Koppad Uday Samrat Sindhu Bindapla Karibasappa Kadappara Mallikarjun Sagar |
| author_facet | Veerabhadrappa Pallavi Sathvika Prathibha Guttal Subhas Debayan Bhattacharjee Vejetha Nagaraj Koppad Uday Samrat Sindhu Bindapla Karibasappa Kadappara Mallikarjun Sagar |
| author_sort | Veerabhadrappa Pallavi Sathvika |
| collection | DOAJ |
| description | Background: The recurring actions and intrusive thoughts that characterise obsessive–compulsive disorder (OCD), a long-term mental illness, are known as compulsions. The cornerstones of conventional treatment are psychological counselling and prescribed medication; nonetheless, interest in complementary therapies has grown. This review looks at how well Ashwagandha, curcumin, milk thistle, valerian root, and St. John’s wort may help with OCD symptoms. Methods: To assess these herbal supplements’ potential for therapeutic benefit, case reports and clinical trials were examined. Results: Curcumin, which contains anti-inflammatory and neuroprotective properties, has shown promise in reducing the severity of OCD symptoms. Traditionally used to treat depression, St. John’s wort has shown some potential in lowering anxiety and compulsive behaviour. The herb milk thistle, which is mainly used for liver protection, did not affect OCD symptoms. Anxiolytic valerian root barely offered relief from symptoms associated with anxiety; it has only little effect on obsessions and compulsions. The adaptive Ashwagandha has demonstrated a great deal of promise in lowering stress and enhancing general well-being, which may help with symptom alleviation. Although the initial results are favourable, larger scale randomised controlled trials are necessary to validate reliability and efficacy. Conclusion: This study illustrates how herbal supplements may be used in addition to conventional medications as adjunctive treatments for OCD. |
| format | Article |
| id | doaj-art-dfcacc557720445c9659d73b0ff2bb4e |
| institution | DOAJ |
| issn | 2813-2998 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Drugs and Drug Candidates |
| spelling | doaj-art-dfcacc557720445c9659d73b0ff2bb4e2025-08-20T02:53:25ZengMDPI AGDrugs and Drug Candidates2813-29982024-12-013483885910.3390/ddc3040047Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive DisorderVeerabhadrappa Pallavi Sathvika0Prathibha Guttal Subhas1Debayan Bhattacharjee2Vejetha Nagaraj Koppad3Uday Samrat4Sindhu Bindapla Karibasappa5Kadappara Mallikarjun Sagar6Department of Pharmacognosy, Bapuji Pharmacy College, Davanagere 577004, IndiaDepartment of Pharmacognosy, Bapuji Pharmacy College, Davanagere 577004, IndiaDepartment of Pharmacognosy, Bapuji Pharmacy College, Davanagere 577004, IndiaDepartment of Pharmacognosy, Bapuji Pharmacy College, Davanagere 577004, IndiaDepartment of Pharmacognosy, Bapuji Pharmacy College, Davanagere 577004, IndiaDepartment of Pharmaceutics, Bapuji Pharmacy College, Davanagere 577004, IndiaDepartment of Pharmaceutical Chemistry, Bapuji Pharmacy College, Davanagere 577004, IndiaBackground: The recurring actions and intrusive thoughts that characterise obsessive–compulsive disorder (OCD), a long-term mental illness, are known as compulsions. The cornerstones of conventional treatment are psychological counselling and prescribed medication; nonetheless, interest in complementary therapies has grown. This review looks at how well Ashwagandha, curcumin, milk thistle, valerian root, and St. John’s wort may help with OCD symptoms. Methods: To assess these herbal supplements’ potential for therapeutic benefit, case reports and clinical trials were examined. Results: Curcumin, which contains anti-inflammatory and neuroprotective properties, has shown promise in reducing the severity of OCD symptoms. Traditionally used to treat depression, St. John’s wort has shown some potential in lowering anxiety and compulsive behaviour. The herb milk thistle, which is mainly used for liver protection, did not affect OCD symptoms. Anxiolytic valerian root barely offered relief from symptoms associated with anxiety; it has only little effect on obsessions and compulsions. The adaptive Ashwagandha has demonstrated a great deal of promise in lowering stress and enhancing general well-being, which may help with symptom alleviation. Although the initial results are favourable, larger scale randomised controlled trials are necessary to validate reliability and efficacy. Conclusion: This study illustrates how herbal supplements may be used in addition to conventional medications as adjunctive treatments for OCD.https://www.mdpi.com/2813-2998/3/4/47obsessive–compulsive disordercurcuminSt. John’s wortmilk thistlevalerian rootAshwagandha |
| spellingShingle | Veerabhadrappa Pallavi Sathvika Prathibha Guttal Subhas Debayan Bhattacharjee Vejetha Nagaraj Koppad Uday Samrat Sindhu Bindapla Karibasappa Kadappara Mallikarjun Sagar Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive Disorder Drugs and Drug Candidates obsessive–compulsive disorder curcumin St. John’s wort milk thistle valerian root Ashwagandha |
| title | Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive Disorder |
| title_full | Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive Disorder |
| title_fullStr | Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive Disorder |
| title_full_unstemmed | Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive Disorder |
| title_short | Review of Case Study Results: Assessing the Effectiveness of Curcumin, St. John’s Wort, Valerian Root, Milk Thistle, and Ashwagandha in the Intervention for Obsessive-Compulsive Disorder |
| title_sort | review of case study results assessing the effectiveness of curcumin st john s wort valerian root milk thistle and ashwagandha in the intervention for obsessive compulsive disorder |
| topic | obsessive–compulsive disorder curcumin St. John’s wort milk thistle valerian root Ashwagandha |
| url | https://www.mdpi.com/2813-2998/3/4/47 |
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