Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case series
Background: Gingival grafts are used to correct mucogingival defects around teeth and implants, but post-operative morbidity, including pain and discomfort, still represents a clinical challenge. Studies using phthalocyanine derivatives (PHY) demonstrated antimicrobial effects, but these substances...
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| Language: | English |
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Universidade Estadual Paulista
2025-05-01
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| Series: | Brazilian Dental Science |
| Online Access: | https://ojs.ict.unesp.br/index.php/cob/article/view/4596 |
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| author | Rafael Sponchiado Cavallieri Caique Andrade Santos Adriana Campos Passanesi Sant`Ana Carla Andreotti Damante Fabiano Vieira Vilhena Mariana Schutzer Ragghianti Zangrando |
| author_facet | Rafael Sponchiado Cavallieri Caique Andrade Santos Adriana Campos Passanesi Sant`Ana Carla Andreotti Damante Fabiano Vieira Vilhena Mariana Schutzer Ragghianti Zangrando |
| author_sort | Rafael Sponchiado Cavallieri |
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Background: Gingival grafts are used to correct mucogingival defects around teeth and implants, but post-operative morbidity, including pain and discomfort, still represents a clinical challenge. Studies using phthalocyanine derivatives (PHY) demonstrated antimicrobial effects, but these substances also seem to present beneficial properties in wound healing. Objective: This case series aimed to evaluate the use of a gel containing 0.1% PHY in the post-operative healing of gingival graft donor sites, with a focus on reducing discomfort and promoting healing. Material and Methods: Five healthy patients were submitted to standardized surgical procedures for root coverage with connective tissue grafts (de-epithelialization technique) and coronal advanced flap. After surgery, they received instructions to use 0.1% PHY gel in palatal donor sites. Clinical and somatosensory parameters were evaluated, as well as analysis of patient-centered outcomes (use of analgesics, difficulty of chewing and pain in the donor areas). Clinically, there was a progressive improvement in wound epithelialization over 30 days, reaching 100% of epithelialization. Results: There was a gradual reduction in the wound area, indicating a favorable trend towards complete healing. Somatosensory analysis revealed superior sensitivity in the donor areas after 60 days, with a decrease after 6 months. The use of analgesics was low, and pain scores were moderate. Conclusion: The use of 0.1% PHY gel seemed to be beneficial in promoting effective and rapid healing in palatal donor sites of gingival grafts. These results indicate that PHY gel may be a promising option for improving clinical results and patients’ quality of life following gingival grafting procedures.
KEYWORDS
Connective tissue; Palate; Phthalocyanine; Quality of life; Wound healing.
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| format | Article |
| id | doaj-art-dfbfaaa01b7b4d7d8751596a4d51b585 |
| institution | Kabale University |
| issn | 2178-6011 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Brazilian Dental Science |
| spelling | doaj-art-dfbfaaa01b7b4d7d8751596a4d51b5852025-08-21T14:05:10ZengUniversidade Estadual PaulistaBrazilian Dental Science2178-60112025-05-0128110.4322/bds.2025.e4596Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case seriesRafael Sponchiado Cavallieri0https://orcid.org/0000-0003-3975-6211Caique Andrade Santos1https://orcid.org/0000-0001-5646-3424Adriana Campos Passanesi Sant`Ana2https://orcid.org/0000-0001-5640-9292Carla Andreotti Damante3https://orcid.org/0000-0002-6782-8596Fabiano Vieira Vilhena4https://orcid.org/0000-0003-3840-3633Mariana Schutzer Ragghianti Zangrando5https://orcid.org/0000-0003-0286-7575Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese e Periodontia. Bauru, SP, Brazil.Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese e Periodontia. Bauru, SP, Brazil.Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese e Periodontia. Bauru, SP, Brazil.Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese e Periodontia. Bauru, SP, Brazil.TRIALS - Saúde Bucal & Tecnologias. Bauru, SP, Brazil.Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Prótese e Periodontia. Bauru, SP, Brazil. Background: Gingival grafts are used to correct mucogingival defects around teeth and implants, but post-operative morbidity, including pain and discomfort, still represents a clinical challenge. Studies using phthalocyanine derivatives (PHY) demonstrated antimicrobial effects, but these substances also seem to present beneficial properties in wound healing. Objective: This case series aimed to evaluate the use of a gel containing 0.1% PHY in the post-operative healing of gingival graft donor sites, with a focus on reducing discomfort and promoting healing. Material and Methods: Five healthy patients were submitted to standardized surgical procedures for root coverage with connective tissue grafts (de-epithelialization technique) and coronal advanced flap. After surgery, they received instructions to use 0.1% PHY gel in palatal donor sites. Clinical and somatosensory parameters were evaluated, as well as analysis of patient-centered outcomes (use of analgesics, difficulty of chewing and pain in the donor areas). Clinically, there was a progressive improvement in wound epithelialization over 30 days, reaching 100% of epithelialization. Results: There was a gradual reduction in the wound area, indicating a favorable trend towards complete healing. Somatosensory analysis revealed superior sensitivity in the donor areas after 60 days, with a decrease after 6 months. The use of analgesics was low, and pain scores were moderate. Conclusion: The use of 0.1% PHY gel seemed to be beneficial in promoting effective and rapid healing in palatal donor sites of gingival grafts. These results indicate that PHY gel may be a promising option for improving clinical results and patients’ quality of life following gingival grafting procedures. KEYWORDS Connective tissue; Palate; Phthalocyanine; Quality of life; Wound healing. https://ojs.ict.unesp.br/index.php/cob/article/view/4596 |
| spellingShingle | Rafael Sponchiado Cavallieri Caique Andrade Santos Adriana Campos Passanesi Sant`Ana Carla Andreotti Damante Fabiano Vieira Vilhena Mariana Schutzer Ragghianti Zangrando Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case series Brazilian Dental Science |
| title | Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case series |
| title_full | Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case series |
| title_fullStr | Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case series |
| title_full_unstemmed | Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case series |
| title_short | Use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal: case series |
| title_sort | use of a gel containing a phthalocyanine derivative in palatal wounds after gingival graft removal case series |
| url | https://ojs.ict.unesp.br/index.php/cob/article/view/4596 |
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