The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review
The oral microbiome is increasingly recognized as a key factor in the development and progression of oral squamous cell carcinoma (OSCC). Dysbiosis has been associated with inflammation and tumorigenesis, highlighting the potential of microbial alterations and salivary biomarkers as tools for early,...
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MDPI AG
2025-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/13/2/373 |
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| author | Ramona Dumitrescu Vanessa Bolchis Aurora Doris Fratila Daniela Jumanca Berivan Laura Rebeca Buzatu Ruxandra Sava-Rosianu Vlad Tiberiu Alexa Atena Galuscan Octavia Balean |
| author_facet | Ramona Dumitrescu Vanessa Bolchis Aurora Doris Fratila Daniela Jumanca Berivan Laura Rebeca Buzatu Ruxandra Sava-Rosianu Vlad Tiberiu Alexa Atena Galuscan Octavia Balean |
| author_sort | Ramona Dumitrescu |
| collection | DOAJ |
| description | The oral microbiome is increasingly recognized as a key factor in the development and progression of oral squamous cell carcinoma (OSCC). Dysbiosis has been associated with inflammation and tumorigenesis, highlighting the potential of microbial alterations and salivary biomarkers as tools for early, non-invasive diagnosis. This review examines recent advancements in understanding the oral microbiome’s role in OSCC. A comprehensive synthesis of studies from 2016 to 2024 was conducted to identify emerging themes and significant findings in the field. Key topics included the interplay between microbiome-driven mechanisms and cancer development, with a focus on microbial communities and their metabolic byproducts. The findings emphasize the importance of specific microbial alterations in modulating immune responses and tumor microenvironments, as well as the promise of biomarkers such as interleukins and miRNA signatures in improving diagnostic accuracy. Recent research trends indicate growing interest in the therapeutic potential of targeting the oral microbiome in OSCC management. Despite significant advancements, gaps remain in the understanding of the precise mechanisms linking dysbiosis to cancer progression. This review underscores the need for continued research to develop personalized diagnostic and therapeutic strategies based on the oral microbiome, with the potential to transform OSCC management. |
| format | Article |
| id | doaj-art-dfbf0bede32c4baea073b52cb13c2f52 |
| institution | OA Journals |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj-art-dfbf0bede32c4baea073b52cb13c2f522025-08-20T02:03:25ZengMDPI AGMicroorganisms2076-26072025-02-0113237310.3390/microorganisms13020373The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic ReviewRamona Dumitrescu0Vanessa Bolchis1Aurora Doris Fratila2Daniela Jumanca3Berivan Laura Rebeca Buzatu4Ruxandra Sava-Rosianu5Vlad Tiberiu Alexa6Atena Galuscan7Octavia Balean8Translational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaTranslational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaFaculty of Dental Medicine, Ludwig Maximilian University of Munich, Goethestrasse 70, 80336 Munich, GermanyTranslational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaTranslational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaTranslational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaTranslational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaTranslational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaTranslational and Experimental Clinical Research Centre in Oral Health, University of Medicine and Pharmacy “Victor Babes”, 300040 Timisoara, RomaniaThe oral microbiome is increasingly recognized as a key factor in the development and progression of oral squamous cell carcinoma (OSCC). Dysbiosis has been associated with inflammation and tumorigenesis, highlighting the potential of microbial alterations and salivary biomarkers as tools for early, non-invasive diagnosis. This review examines recent advancements in understanding the oral microbiome’s role in OSCC. A comprehensive synthesis of studies from 2016 to 2024 was conducted to identify emerging themes and significant findings in the field. Key topics included the interplay between microbiome-driven mechanisms and cancer development, with a focus on microbial communities and their metabolic byproducts. The findings emphasize the importance of specific microbial alterations in modulating immune responses and tumor microenvironments, as well as the promise of biomarkers such as interleukins and miRNA signatures in improving diagnostic accuracy. Recent research trends indicate growing interest in the therapeutic potential of targeting the oral microbiome in OSCC management. Despite significant advancements, gaps remain in the understanding of the precise mechanisms linking dysbiosis to cancer progression. This review underscores the need for continued research to develop personalized diagnostic and therapeutic strategies based on the oral microbiome, with the potential to transform OSCC management.https://www.mdpi.com/2076-2607/13/2/373VOSviewermicrobiomeOSCCsalivary biomarkers |
| spellingShingle | Ramona Dumitrescu Vanessa Bolchis Aurora Doris Fratila Daniela Jumanca Berivan Laura Rebeca Buzatu Ruxandra Sava-Rosianu Vlad Tiberiu Alexa Atena Galuscan Octavia Balean The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review Microorganisms VOSviewer microbiome OSCC salivary biomarkers |
| title | The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review |
| title_full | The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review |
| title_fullStr | The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review |
| title_full_unstemmed | The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review |
| title_short | The Global Trends and Advances in Oral Microbiome Research on Oral Squamous Cell Carcinoma: A Systematic Review |
| title_sort | global trends and advances in oral microbiome research on oral squamous cell carcinoma a systematic review |
| topic | VOSviewer microbiome OSCC salivary biomarkers |
| url | https://www.mdpi.com/2076-2607/13/2/373 |
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