ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES
Objective. This study was devoted to examinationof some factors of blood coagulation (factor II, factor VII, factor XII, antithrombin III) in order to find their associations with biomarkers of endothelial dysfunction (endothelin 1, monocyticchemoattractant protein type 1, MCP-1, lipoprotein (a), LP...
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«FIRMA «SILICEA» LLC
2018-09-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/2744 |
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| author | Yu. I. Ragino E. V. Striukova I. S. Murashov Ya. V. Polonskaya A. M. Volkov E. V. Kashtanova A. V. Kurguzov A. M. Chernjavskii |
| author_facet | Yu. I. Ragino E. V. Striukova I. S. Murashov Ya. V. Polonskaya A. M. Volkov E. V. Kashtanova A. V. Kurguzov A. M. Chernjavskii |
| author_sort | Yu. I. Ragino |
| collection | DOAJ |
| description | Objective. This study was devoted to examinationof some factors of blood coagulation (factor II, factor VII, factor XII, antithrombin III) in order to find their associations with biomarkers of endothelial dysfunction (endothelin 1, monocyticchemoattractant protein type 1, MCP-1, lipoprotein (a), LP (a), adhesive molecules sVCAM-1, asymmetric dimethylarginin, ADMA, homocysteine), inflammation (interleukins, IL-6, IL - 8, C-reactive protein, CRP) and with unstable atherosclerotic plaques in the coronary arteries in men with coronary atherosclerosis.Material and methods. In 93 men with coronary atherosclerosis without acute coronary syndrome, blood coagulation factors concentrations (factor II, factor VII, factor XII, antithrombin III) were studied in the blood with goal to find their associations with biomarkers of endothelial dysfunction (endothelin 1, MCP-1, LP(a), adhesion molecules sVCAM-1, ADMA, homocysteine), of inflammation (IL-6, IL-8, CRP) and with the presence of unstable plaques in the coronary arteries.Results. In men with unstable atherosclerotic plaques in the coronary arteries, the blood levels of factor VII and factor XII were 1.3 and 1.3 times higher, respectively, compared to men who had stable plaques in the coronary arteries. Correlation links between the blood levels of factor II and factor XII and the presence of unstable atherosclerotic plaques in the coronary arteries (r=0.239 and r=0.250, p <0.05, respectively) have been revealed, as well as between coagulation factors and blood levels of LP(a), sVCAM-1, IL-6 and CRP. Results of logistic regression analysis showed that the relative risk of present of unstable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII (OR=1.008, 95 % CI 1.000-1.017, p=0.048).Conclusion. Our results indicate that elevated blood levels of the Hageman factor may be a new biomarker of probability of unstable atherosclerotic plaques presence in the coronary arteries. |
| format | Article |
| id | doaj-art-dfbea42482d846409b60ae35796ff049 |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-dfbea42482d846409b60ae35796ff0492025-08-20T02:59:07Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202018-09-0108212410.15829/1560-4071-2018-8-21-242409ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIESYu. I. Ragino0E. V. Striukova1I. S. Murashov2Ya. V. Polonskaya3A. M. Volkov4E. V. Kashtanova5A. V. Kurguzov6A. M. Chernjavskii7Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics of SD RASResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics of SD RASE. N. Meshalkin National Medical Research Center of the Ministry of HealthResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics of SD RASE. N. Meshalkin National Medical Research Center of the Ministry of HealthResearch Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics of SD RASE. N. Meshalkin National Medical Research Center of the Ministry of HealthE. N. Meshalkin National Medical Research Center of the Ministry of HealthObjective. This study was devoted to examinationof some factors of blood coagulation (factor II, factor VII, factor XII, antithrombin III) in order to find their associations with biomarkers of endothelial dysfunction (endothelin 1, monocyticchemoattractant protein type 1, MCP-1, lipoprotein (a), LP (a), adhesive molecules sVCAM-1, asymmetric dimethylarginin, ADMA, homocysteine), inflammation (interleukins, IL-6, IL - 8, C-reactive protein, CRP) and with unstable atherosclerotic plaques in the coronary arteries in men with coronary atherosclerosis.Material and methods. In 93 men with coronary atherosclerosis without acute coronary syndrome, blood coagulation factors concentrations (factor II, factor VII, factor XII, antithrombin III) were studied in the blood with goal to find their associations with biomarkers of endothelial dysfunction (endothelin 1, MCP-1, LP(a), adhesion molecules sVCAM-1, ADMA, homocysteine), of inflammation (IL-6, IL-8, CRP) and with the presence of unstable plaques in the coronary arteries.Results. In men with unstable atherosclerotic plaques in the coronary arteries, the blood levels of factor VII and factor XII were 1.3 and 1.3 times higher, respectively, compared to men who had stable plaques in the coronary arteries. Correlation links between the blood levels of factor II and factor XII and the presence of unstable atherosclerotic plaques in the coronary arteries (r=0.239 and r=0.250, p <0.05, respectively) have been revealed, as well as between coagulation factors and blood levels of LP(a), sVCAM-1, IL-6 and CRP. Results of logistic regression analysis showed that the relative risk of present of unstable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII (OR=1.008, 95 % CI 1.000-1.017, p=0.048).Conclusion. Our results indicate that elevated blood levels of the Hageman factor may be a new biomarker of probability of unstable atherosclerotic plaques presence in the coronary arteries.https://russjcardiol.elpub.ru/jour/article/view/2744coagulation factorsinflammation markersendothelial dysfunction markersstable and unstable atherosclerotic plaquesblood |
| spellingShingle | Yu. I. Ragino E. V. Striukova I. S. Murashov Ya. V. Polonskaya A. M. Volkov E. V. Kashtanova A. V. Kurguzov A. M. Chernjavskii ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES Российский кардиологический журнал coagulation factors inflammation markers endothelial dysfunction markers stable and unstable atherosclerotic plaques blood |
| title | ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES |
| title_full | ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES |
| title_fullStr | ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES |
| title_full_unstemmed | ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES |
| title_short | ASSOCIATION OF COAGULATION FACTORS WITH THE PRESENCE OF UNSTABLE ATHEROSCLEROTIC PLAQUES IN THE CORONARY ARTERIES |
| title_sort | association of coagulation factors with the presence of unstable atherosclerotic plaques in the coronary arteries |
| topic | coagulation factors inflammation markers endothelial dysfunction markers stable and unstable atherosclerotic plaques blood |
| url | https://russjcardiol.elpub.ru/jour/article/view/2744 |
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