Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer’s disease by activating the Wnt/β-catenin signaling

Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer’s disease by activating the Wnt/β-catenin signaling

Abstract Microglia and exosomes are intimately connected with the pathogenesis of Alzheimer’s disease (AD). We aim to investigate the role and potential mechanisms of M2-like (anti-inflammatory) microglia-derived exosomes (M2-Exos) in AD. We utilized an Aβ1−42-induced AD model in HT-22 neurons and m...

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Bibliographic Details
Main Authors: Ling Zhu, Tao Zhou, Lei Wu, Xuanang Zhu, Lvan Chen, Mi Zhang, Jing Zhou, Fan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Alzheimer’s disease
M2-like microglia
Exosomes
TREM2
Wnt/β-catenin pathway
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-09563-1
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