Pathogenicity and virulence of Clostridioides difficile
Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality. Treatment is complex, since antibiotics constitute both the main treatment and the major...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Virulence |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2022.2150452 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849426746180370432 |
|---|---|
| author | Jessica E. Buddle Robert P. Fagan |
| author_facet | Jessica E. Buddle Robert P. Fagan |
| author_sort | Jessica E. Buddle |
| collection | DOAJ |
| description | Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality. Treatment is complex, since antibiotics constitute both the main treatment and the major risk factor for infection. Worryingly, resistance to multiple antibiotics is becoming increasingly widespread, leading to the classification of this pathogen as an urgent threat to global health. As a consummate opportunist, C. difficile is well equipped for promoting disease, owing to its arsenal of virulence factors: transmission of this anaerobe is highly efficient due to the formation of robust endospores, and an array of adhesins promote gut colonization. C. difficile produces multiple toxins acting upon gut epithelia, resulting in manifestations typical of diarrheal disease, and severe inflammation in a subset of patients. This review focuses on such virulence factors, as well as the importance of antimicrobial resistance and genome plasticity in enabling pathogenesis and persistence of this important pathogen. |
| format | Article |
| id | doaj-art-dfb2a56612714bdfa6f8c2c51c9c45d0 |
| institution | Kabale University |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-dfb2a56612714bdfa6f8c2c51c9c45d02025-08-20T03:29:15ZengTaylor & Francis GroupVirulence2150-55942150-56082023-12-0114110.1080/21505594.2022.2150452Pathogenicity and virulence of Clostridioides difficileJessica E. Buddle0Robert P. Fagan1Molecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, UKMolecular Microbiology, School of Biosciences, University of Sheffield, Sheffield, UKClostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality. Treatment is complex, since antibiotics constitute both the main treatment and the major risk factor for infection. Worryingly, resistance to multiple antibiotics is becoming increasingly widespread, leading to the classification of this pathogen as an urgent threat to global health. As a consummate opportunist, C. difficile is well equipped for promoting disease, owing to its arsenal of virulence factors: transmission of this anaerobe is highly efficient due to the formation of robust endospores, and an array of adhesins promote gut colonization. C. difficile produces multiple toxins acting upon gut epithelia, resulting in manifestations typical of diarrheal disease, and severe inflammation in a subset of patients. This review focuses on such virulence factors, as well as the importance of antimicrobial resistance and genome plasticity in enabling pathogenesis and persistence of this important pathogen.https://www.tandfonline.com/doi/10.1080/21505594.2022.2150452c. difficilevirulence factorsantimicrobial resistancetoxinssporesCDI |
| spellingShingle | Jessica E. Buddle Robert P. Fagan Pathogenicity and virulence of Clostridioides difficile Virulence c. difficile virulence factors antimicrobial resistance toxins spores CDI |
| title | Pathogenicity and virulence of Clostridioides difficile |
| title_full | Pathogenicity and virulence of Clostridioides difficile |
| title_fullStr | Pathogenicity and virulence of Clostridioides difficile |
| title_full_unstemmed | Pathogenicity and virulence of Clostridioides difficile |
| title_short | Pathogenicity and virulence of Clostridioides difficile |
| title_sort | pathogenicity and virulence of clostridioides difficile |
| topic | c. difficile virulence factors antimicrobial resistance toxins spores CDI |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2022.2150452 |
| work_keys_str_mv | AT jessicaebuddle pathogenicityandvirulenceofclostridioidesdifficile AT robertpfagan pathogenicityandvirulenceofclostridioidesdifficile |