Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa

Decreased dihydroartemisinin-piperaquine protection against recurrent malaria associated with Plasmodium falciparum plasmepsin 3 copy number variation in Africa

Abstract Dihydroartemisinin-piperaquine (DHA-PPQ) is being recommended in Africa for the management of uncomplicated Plasmodium falciparum malaria and for chemoprevention strategies, based on the ability of piperaquine to delay re-infections. Although therapeutic resistance to piperaquine has been l...

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Main Authors: Leyre Pernaute-Lau, Mario Recker, Mamadou Tékété, Tais Nóbrega de Sousa, Aliou Traore, Bakary Fofana, Kassim Sanogo, Ulrika Morris, Juliana Inoue, Pedro E. Ferreira, Nouhoum Diallo, Jürgen Burhenne, Issaka Sagara, Alassane Dicko, Maria I. Veiga, Walter Haefeli, Anders Björkman, Abdoulaye A. Djimde, Steffen Borrmann, José Pedro Gil
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57726-5
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