Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice
Abstract Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chronic administration of LNA‐miR‐29 into an atheroscle...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2016-05-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201506031 |
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| author | Victoria Ulrich Noemi Rotllan Elisa Araldi Amelia Luciano Philipp Skroblin Mélanie Abonnenc Paola Perrotta Xiaoke Yin Ashley Bauer Kristen L Leslie Pei Zhang Binod Aryal Rusty L Montgomery Thomas Thum Kathleen Martin Yajaira Suarez Manuel Mayr Carlos Fernandez‐Hernando William C Sessa |
| author_facet | Victoria Ulrich Noemi Rotllan Elisa Araldi Amelia Luciano Philipp Skroblin Mélanie Abonnenc Paola Perrotta Xiaoke Yin Ashley Bauer Kristen L Leslie Pei Zhang Binod Aryal Rusty L Montgomery Thomas Thum Kathleen Martin Yajaira Suarez Manuel Mayr Carlos Fernandez‐Hernando William C Sessa |
| author_sort | Victoria Ulrich |
| collection | DOAJ |
| description | Abstract Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chronic administration of LNA‐miR‐29 into an atherosclerotic mouse model improves indices of plaque morphology. This occurs due to upregulation of miR‐29 target genes of the ECM (col1A and col3A) resulting in reduced lesion size, enhanced fibrous cap thickness, and reduced necrotic zones. Sustained LNA‐miR‐29 treatment did not affect circulating lipids, blood chemistry, or ECM of solid organs including liver, lung, kidney, spleen, or heart. Collectively, these data support the idea that antagonizing miR‐29 may promote beneficial plaque remodeling as an independent approach to stabilize vulnerable atherosclerotic lesions. |
| format | Article |
| id | doaj-art-dfae49429d474f239ee09a30e0002d2d |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2016-05-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-dfae49429d474f239ee09a30e0002d2d2025-08-20T04:02:55ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842016-05-018664365310.15252/emmm.201506031Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic miceVictoria Ulrich0Noemi Rotllan1Elisa Araldi2Amelia Luciano3Philipp Skroblin4Mélanie Abonnenc5Paola Perrotta6Xiaoke Yin7Ashley Bauer8Kristen L Leslie9Pei Zhang10Binod Aryal11Rusty L Montgomery12Thomas Thum13Kathleen Martin14Yajaira Suarez15Manuel Mayr16Carlos Fernandez‐Hernando17William C Sessa18Vascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineKing's British Heart Foundation Centre, King's College LondonKing's British Heart Foundation Centre, King's College LondonVascular Biology and Therapeutics Program, Yale University School of MedicineKing's British Heart Foundation Centre, King's College LondonVascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicinemiRagen TherapeuticsInstitute of Molecular and Translational Therapeutic Strategies, Hannover Medical SchoolVascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineKing's British Heart Foundation Centre, King's College LondonVascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineAbstract Abnormal remodeling of atherosclerotic plaques can lead to rupture, acute myocardial infarction, and death. Enhancement of plaque extracellular matrix (ECM) may improve plaque morphology and stabilize lesions. Here, we demonstrate that chronic administration of LNA‐miR‐29 into an atherosclerotic mouse model improves indices of plaque morphology. This occurs due to upregulation of miR‐29 target genes of the ECM (col1A and col3A) resulting in reduced lesion size, enhanced fibrous cap thickness, and reduced necrotic zones. Sustained LNA‐miR‐29 treatment did not affect circulating lipids, blood chemistry, or ECM of solid organs including liver, lung, kidney, spleen, or heart. Collectively, these data support the idea that antagonizing miR‐29 may promote beneficial plaque remodeling as an independent approach to stabilize vulnerable atherosclerotic lesions.https://doi.org/10.15252/emmm.201506031atherosclerosisLNAmiR‐29plaquestability |
| spellingShingle | Victoria Ulrich Noemi Rotllan Elisa Araldi Amelia Luciano Philipp Skroblin Mélanie Abonnenc Paola Perrotta Xiaoke Yin Ashley Bauer Kristen L Leslie Pei Zhang Binod Aryal Rusty L Montgomery Thomas Thum Kathleen Martin Yajaira Suarez Manuel Mayr Carlos Fernandez‐Hernando William C Sessa Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice EMBO Molecular Medicine atherosclerosis LNA miR‐29 plaque stability |
| title | Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice |
| title_full | Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice |
| title_fullStr | Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice |
| title_full_unstemmed | Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice |
| title_short | Chronic miR‐29 antagonism promotes favorable plaque remodeling in atherosclerotic mice |
| title_sort | chronic mir 29 antagonism promotes favorable plaque remodeling in atherosclerotic mice |
| topic | atherosclerosis LNA miR‐29 plaque stability |
| url | https://doi.org/10.15252/emmm.201506031 |
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