Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis.
<h4>Background</h4>There is widespread concern about the possible health effects of traffic-related air pollution. Nitrogen dioxide (NO2) is a convenient marker of primary pollution. We investigated the associations between lung function and current residential exposure to a range of air...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0142565&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331927500193792 |
|---|---|
| author | Francesco Barone-Adesi Jennifer E Dent David Dajnak Sean Beevers H Ross Anderson Frank J Kelly Derek G Cook Peter H Whincup |
| author_facet | Francesco Barone-Adesi Jennifer E Dent David Dajnak Sean Beevers H Ross Anderson Frank J Kelly Derek G Cook Peter H Whincup |
| author_sort | Francesco Barone-Adesi |
| collection | DOAJ |
| description | <h4>Background</h4>There is widespread concern about the possible health effects of traffic-related air pollution. Nitrogen dioxide (NO2) is a convenient marker of primary pollution. We investigated the associations between lung function and current residential exposure to a range of air pollutants (particularly NO2, NO, NOx and particulate matter) in London children. Moreover, we placed the results for NO2 in context with a meta-analysis of published estimates of the association.<h4>Methods and findings</h4>Associations between primary traffic pollutants and lung function were investigated in 4884 children aged 9-10 years who participated in the Child Heart and Health Study in England (CHASE). A systematic literature search identified 13 studies eligible for inclusion in a meta-analysis. We combined results from the meta-analysis with the distribution of the values of FEV1 in CHASE to estimate the prevalence of children with abnormal lung function (FEV1<80% of predicted value) expected under different scenarios of NO2 exposure. In CHASE, there were non-significant inverse associations between all pollutants except ozone and both FEV1 and FVC. In the meta-analysis, a 10 μg/m3 increase in NO2 was associated with an 8 ml lower FEV1 (95% CI: -14 to -1 ml; p: 0.016). The observed effect was not modified by a reported asthma diagnosis. On the basis of these results, a 10 μg/m3 increase in NO2 level would translate into a 7% (95% CI: 4% to 12%) increase of the prevalence of children with abnormal lung function.<h4>Conclusions</h4>Exposure to traffic pollution may cause a small overall reduction in lung function and increase the prevalence of children with clinically relevant declines in lung function. |
| format | Article |
| id | doaj-art-dfadcb0d672146fb8d436e0057f66d78 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-dfadcb0d672146fb8d436e0057f66d782025-08-20T03:46:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011011e014256510.1371/journal.pone.0142565Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis.Francesco Barone-AdesiJennifer E DentDavid DajnakSean BeeversH Ross AndersonFrank J KellyDerek G CookPeter H Whincup<h4>Background</h4>There is widespread concern about the possible health effects of traffic-related air pollution. Nitrogen dioxide (NO2) is a convenient marker of primary pollution. We investigated the associations between lung function and current residential exposure to a range of air pollutants (particularly NO2, NO, NOx and particulate matter) in London children. Moreover, we placed the results for NO2 in context with a meta-analysis of published estimates of the association.<h4>Methods and findings</h4>Associations between primary traffic pollutants and lung function were investigated in 4884 children aged 9-10 years who participated in the Child Heart and Health Study in England (CHASE). A systematic literature search identified 13 studies eligible for inclusion in a meta-analysis. We combined results from the meta-analysis with the distribution of the values of FEV1 in CHASE to estimate the prevalence of children with abnormal lung function (FEV1<80% of predicted value) expected under different scenarios of NO2 exposure. In CHASE, there were non-significant inverse associations between all pollutants except ozone and both FEV1 and FVC. In the meta-analysis, a 10 μg/m3 increase in NO2 was associated with an 8 ml lower FEV1 (95% CI: -14 to -1 ml; p: 0.016). The observed effect was not modified by a reported asthma diagnosis. On the basis of these results, a 10 μg/m3 increase in NO2 level would translate into a 7% (95% CI: 4% to 12%) increase of the prevalence of children with abnormal lung function.<h4>Conclusions</h4>Exposure to traffic pollution may cause a small overall reduction in lung function and increase the prevalence of children with clinically relevant declines in lung function.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0142565&type=printable |
| spellingShingle | Francesco Barone-Adesi Jennifer E Dent David Dajnak Sean Beevers H Ross Anderson Frank J Kelly Derek G Cook Peter H Whincup Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis. PLoS ONE |
| title | Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis. |
| title_full | Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis. |
| title_fullStr | Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis. |
| title_full_unstemmed | Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis. |
| title_short | Long-Term Exposure to Primary Traffic Pollutants and Lung Function in Children: Cross-Sectional Study and Meta-Analysis. |
| title_sort | long term exposure to primary traffic pollutants and lung function in children cross sectional study and meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0142565&type=printable |
| work_keys_str_mv | AT francescobaroneadesi longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis AT jenniferedent longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis AT daviddajnak longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis AT seanbeevers longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis AT hrossanderson longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis AT frankjkelly longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis AT derekgcook longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis AT peterhwhincup longtermexposuretoprimarytrafficpollutantsandlungfunctioninchildrencrosssectionalstudyandmetaanalysis |