Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems
Objective: Maternal thyroid peroxidase antibody (TPOAb) positivity has been associated with a variety of pregnancy complications and has potential neuropsychological developmental implications for the offspring. The aim of our study was to explore the effect of maternal TPOAb levels on emotional and...
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Bioscientifica
2025-04-01
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| Series: | European Thyroid Journal |
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| Online Access: | https://etj.bioscientifica.com/view/journals/etj/14/2/ETJ-24-0302.xml |
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| author | Penggui Wu Mengting Yang Yuzhu Teng Jiajun Ouyang Wenjin Cai Juan Tong Guopeng Gao Xiaoyan Wu Yan Han Shuangqin Yan Fangbiao Tao Kun Huang |
| author_facet | Penggui Wu Mengting Yang Yuzhu Teng Jiajun Ouyang Wenjin Cai Juan Tong Guopeng Gao Xiaoyan Wu Yan Han Shuangqin Yan Fangbiao Tao Kun Huang |
| author_sort | Penggui Wu |
| collection | DOAJ |
| description | Objective: Maternal thyroid peroxidase antibody (TPOAb) positivity has been associated with a variety of pregnancy complications and has potential neuropsychological developmental implications for the offspring. The aim of our study was to explore the effect of maternal TPOAb levels on emotional and behavioral problems in children. Design: The study was designed as a cohort study. Participants: Based on the Ma’anshan birth cohort in China, 2,464 mother-infant pairs were included in this study. Measurements: Repeated blood samples were collected from pregnant women, and TPOAb and FT4 were measured retrospectively by electrochemiluminescence immunoassay (ECLIA). The strengths and difficulties questionnaire was used to assess the emotional and behavioral problems of 4-year-old preschoolers. Results: After adjusting for potential confounders, maternal TPOAb positivity during the third trimester of pregnancy was found to be associated with an elevated risk of conduct problems in girls, with an odds ratio (OR) of 2.190 (95% confidence interval (CI): 1.137–4.219). Conversely, maternal TPOAb positivity in the first trimester was linked to a decreased incidence of prosocial behavior in boys, with an OR of 0.451 (95% CI: 0.237–0.861). Conclusions: Maternal TPOAb positivity during pregnancy may be associated with emotional and behavioral problems in preschool-aged children. |
| format | Article |
| id | doaj-art-dfab257a5c01414082ba010fca1b1652 |
| institution | OA Journals |
| issn | 2235-0802 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj-art-dfab257a5c01414082ba010fca1b16522025-08-20T02:19:19ZengBioscientificaEuropean Thyroid Journal2235-08022025-04-0114210.1530/ETJ-24-03021Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problemsPenggui Wu0Mengting Yang1Yuzhu Teng2Jiajun Ouyang3Wenjin Cai4Juan Tong5Guopeng Gao6Xiaoyan Wu7Yan Han8Shuangqin Yan9Fangbiao Tao10Kun Huang11Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaMaternal and Child Health Center in Ma’anshan, Ma’anshan, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaSchool of Public Health, Xuzhou Medical University, Xuzhou, ChinaMaternal and Child Health Center in Ma’anshan, Ma’anshan, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaDepartment of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei, Anhui, ChinaObjective: Maternal thyroid peroxidase antibody (TPOAb) positivity has been associated with a variety of pregnancy complications and has potential neuropsychological developmental implications for the offspring. The aim of our study was to explore the effect of maternal TPOAb levels on emotional and behavioral problems in children. Design: The study was designed as a cohort study. Participants: Based on the Ma’anshan birth cohort in China, 2,464 mother-infant pairs were included in this study. Measurements: Repeated blood samples were collected from pregnant women, and TPOAb and FT4 were measured retrospectively by electrochemiluminescence immunoassay (ECLIA). The strengths and difficulties questionnaire was used to assess the emotional and behavioral problems of 4-year-old preschoolers. Results: After adjusting for potential confounders, maternal TPOAb positivity during the third trimester of pregnancy was found to be associated with an elevated risk of conduct problems in girls, with an odds ratio (OR) of 2.190 (95% confidence interval (CI): 1.137–4.219). Conversely, maternal TPOAb positivity in the first trimester was linked to a decreased incidence of prosocial behavior in boys, with an OR of 0.451 (95% CI: 0.237–0.861). Conclusions: Maternal TPOAb positivity during pregnancy may be associated with emotional and behavioral problems in preschool-aged children.https://etj.bioscientifica.com/view/journals/etj/14/2/ETJ-24-0302.xmlthyroid peroxidase antibodythyroid hormonethyroid hormone trajectoriesemotional and behavioral problemspregnancypreschool children |
| spellingShingle | Penggui Wu Mengting Yang Yuzhu Teng Jiajun Ouyang Wenjin Cai Juan Tong Guopeng Gao Xiaoyan Wu Yan Han Shuangqin Yan Fangbiao Tao Kun Huang Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems European Thyroid Journal thyroid peroxidase antibody thyroid hormone thyroid hormone trajectories emotional and behavioral problems pregnancy preschool children |
| title | Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems |
| title_full | Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems |
| title_fullStr | Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems |
| title_full_unstemmed | Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems |
| title_short | Association of maternal thyroid peroxidase antibody exposure with children’s emotional and behavioral problems |
| title_sort | association of maternal thyroid peroxidase antibody exposure with children s emotional and behavioral problems |
| topic | thyroid peroxidase antibody thyroid hormone thyroid hormone trajectories emotional and behavioral problems pregnancy preschool children |
| url | https://etj.bioscientifica.com/view/journals/etj/14/2/ETJ-24-0302.xml |
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