Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways
There is increased investigation of the human microbiome as it relates to health and disease. Dysbiosis is implicated in various clinical conditions including inflammatory bowel disease (IBD). Probiotics have b...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/971938 |
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| _version_ | 1850167821778026496 |
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| author | Sonia S. Yoon Jun Sun |
| author_facet | Sonia S. Yoon Jun Sun |
| author_sort | Sonia S. Yoon |
| collection | DOAJ |
| description | There is increased investigation of the human microbiome as it relates to
health and disease. Dysbiosis is implicated in various clinical
conditions including inflammatory bowel disease (IBD). Probiotics have
been explored as a potential treatment for IBD and other diseases. The
mechanism of action for probiotics has yet to be fully elucidated.
This paper discusses novel mechanisms of action for probiotics
involving anti-inflammatory signaling pathways. We highlight recent
progress in probiotics and nuclear receptor signaling, such as
peroxisome-proliferator-activated receptor gamma (PPARγ) and vitamin D receptor (VDR). We also discuss future
areas of investigation. |
| format | Article |
| id | doaj-art-dfab08c6111d4c539107e24d2a25537c |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-dfab08c6111d4c539107e24d2a25537c2025-08-20T02:21:07ZengWileyGastroenterology Research and Practice1687-61211687-630X2011-01-01201110.1155/2011/971938971938Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory PathwaysSonia S. Yoon0Jun Sun1Division of Gastroenterology and Hepatology, Department of Medicine, Strong Memorial Hospital, University of Rochester Mediacal Center, University of Rochester, Rochester, NY 14642, USADivision of Gastroenterology and Hepatology, Department of Medicine, Strong Memorial Hospital, University of Rochester Mediacal Center, University of Rochester, Rochester, NY 14642, USAThere is increased investigation of the human microbiome as it relates to health and disease. Dysbiosis is implicated in various clinical conditions including inflammatory bowel disease (IBD). Probiotics have been explored as a potential treatment for IBD and other diseases. The mechanism of action for probiotics has yet to be fully elucidated. This paper discusses novel mechanisms of action for probiotics involving anti-inflammatory signaling pathways. We highlight recent progress in probiotics and nuclear receptor signaling, such as peroxisome-proliferator-activated receptor gamma (PPARγ) and vitamin D receptor (VDR). We also discuss future areas of investigation.http://dx.doi.org/10.1155/2011/971938 |
| spellingShingle | Sonia S. Yoon Jun Sun Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways Gastroenterology Research and Practice |
| title | Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory
Pathways |
| title_full | Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory
Pathways |
| title_fullStr | Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory
Pathways |
| title_full_unstemmed | Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory
Pathways |
| title_short | Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory
Pathways |
| title_sort | probiotics nuclear receptor signaling and anti inflammatory pathways |
| url | http://dx.doi.org/10.1155/2011/971938 |
| work_keys_str_mv | AT soniasyoon probioticsnuclearreceptorsignalingandantiinflammatorypathways AT junsun probioticsnuclearreceptorsignalingandantiinflammatorypathways |