Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways
There is increased investigation of the human microbiome as it relates to health and disease. Dysbiosis is implicated in various clinical conditions including inflammatory bowel disease (IBD). Probiotics have b...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/971938 |
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| Summary: | There is increased investigation of the human microbiome as it relates to
health and disease. Dysbiosis is implicated in various clinical
conditions including inflammatory bowel disease (IBD). Probiotics have
been explored as a potential treatment for IBD and other diseases. The
mechanism of action for probiotics has yet to be fully elucidated.
This paper discusses novel mechanisms of action for probiotics
involving anti-inflammatory signaling pathways. We highlight recent
progress in probiotics and nuclear receptor signaling, such as
peroxisome-proliferator-activated receptor gamma (PPARγ) and vitamin D receptor (VDR). We also discuss future
areas of investigation. |
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| ISSN: | 1687-6121 1687-630X |