Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi
Candida fungi exploit various virulence strategies to invade the human host, while host cells employ diverse mechanisms to maintain homeostasis and respond to infection. Extracellular vesicles (EVs) are integral components of the multifaceted landscape of host-pathogen interactions, with their abund...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517424000373 |
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| author | Kamila Kulig Maria Rapala-Kozik Justyna Karkowska-Kuleta |
| author_facet | Kamila Kulig Maria Rapala-Kozik Justyna Karkowska-Kuleta |
| author_sort | Kamila Kulig |
| collection | DOAJ |
| description | Candida fungi exploit various virulence strategies to invade the human host, while host cells employ diverse mechanisms to maintain homeostasis and respond to infection. Extracellular vesicles (EVs) are integral components of the multifaceted landscape of host-pathogen interactions, with their abundant production by all contributors involved in these complex and dynamic relations. Herein, we present the current state of knowledge regarding the host response by releasing EVs in reaction to Candida, as well as the influence of fungal EVs on the functionality of the confronted host cells. Fungal vesicles contribute to enhanced adhesion of pathogens to human cells as evidenced for C. auris, and may modulate the production of several cytokines, including IL-6, IL-8, IL-10, IL-12p40, TGF-β and TNF-α, thereby exerting pro-infective and pro-inflammatory effects, as described for C. albicans and other Candida species. Whereas the biosynthesis of EVs by host cells can dynamically modulate the proliferation and viability of fungal cells and affect the candidacidal functionality of other effector cells. The reciprocal influence of EVs from host cells and Candida pathogens is a key focus, explaining their significant role in cell signaling and interkingdom communication. |
| format | Article |
| id | doaj-art-dfa7990080be4f209ebfae6c493939f3 |
| institution | OA Journals |
| issn | 2666-5174 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-dfa7990080be4f209ebfae6c493939f32025-08-20T02:19:51ZengElsevierCurrent Research in Microbial Sciences2666-51742024-01-01710025510.1016/j.crmicr.2024.100255Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungiKamila Kulig0Maria Rapala-Kozik1Justyna Karkowska-Kuleta2Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, PolandDepartment of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, PolandCorresponding author.; Department of Comparative Biochemistry and Bioanalytics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Gronostajowa 7, 30-387 Kraków, PolandCandida fungi exploit various virulence strategies to invade the human host, while host cells employ diverse mechanisms to maintain homeostasis and respond to infection. Extracellular vesicles (EVs) are integral components of the multifaceted landscape of host-pathogen interactions, with their abundant production by all contributors involved in these complex and dynamic relations. Herein, we present the current state of knowledge regarding the host response by releasing EVs in reaction to Candida, as well as the influence of fungal EVs on the functionality of the confronted host cells. Fungal vesicles contribute to enhanced adhesion of pathogens to human cells as evidenced for C. auris, and may modulate the production of several cytokines, including IL-6, IL-8, IL-10, IL-12p40, TGF-β and TNF-α, thereby exerting pro-infective and pro-inflammatory effects, as described for C. albicans and other Candida species. Whereas the biosynthesis of EVs by host cells can dynamically modulate the proliferation and viability of fungal cells and affect the candidacidal functionality of other effector cells. The reciprocal influence of EVs from host cells and Candida pathogens is a key focus, explaining their significant role in cell signaling and interkingdom communication.http://www.sciencedirect.com/science/article/pii/S2666517424000373Extracellular vesiclesFungiCandidaInflammationHost responseMacrophages |
| spellingShingle | Kamila Kulig Maria Rapala-Kozik Justyna Karkowska-Kuleta Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi Current Research in Microbial Sciences Extracellular vesicles Fungi Candida Inflammation Host response Macrophages |
| title | Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi |
| title_full | Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi |
| title_fullStr | Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi |
| title_full_unstemmed | Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi |
| title_short | Extracellular vesicle production: A bidirectional effect in the interplay between host and Candida fungi |
| title_sort | extracellular vesicle production a bidirectional effect in the interplay between host and candida fungi |
| topic | Extracellular vesicles Fungi Candida Inflammation Host response Macrophages |
| url | http://www.sciencedirect.com/science/article/pii/S2666517424000373 |
| work_keys_str_mv | AT kamilakulig extracellularvesicleproductionabidirectionaleffectintheinterplaybetweenhostandcandidafungi AT mariarapalakozik extracellularvesicleproductionabidirectionaleffectintheinterplaybetweenhostandcandidafungi AT justynakarkowskakuleta extracellularvesicleproductionabidirectionaleffectintheinterplaybetweenhostandcandidafungi |