The influence of catalysis on mad2 activation dynamics.

The influence of catalysis on mad2 activation dynamics.

Mad2 is a key component of the spindle assembly checkpoint, a safety device ensuring faithful sister chromatid separation in mitosis. The target of Mad2 is Cdc20, an activator of the anaphase-promoting complex/cyclosome (APC/C). Mad2 binding to Cdc20 is a complex reaction that entails the conformati...

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Bibliographic Details
Main Authors: Marco Simonetta, Romilde Manzoni, Roberto Mosca, Marina Mapelli, Lucia Massimiliano, Martin Vink, Bela Novak, Andrea Musacchio, Andrea Ciliberto
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1000010&type=printable
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