Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma
We aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse tumor model. The tumor volume was then detected. sirt1 was over-expressed significantly in ESCC patients and cells. Moreov...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Cancer Biology & Therapy |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15384047.2024.2365449 |
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| _version_ | 1850108838972227584 |
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| author | Xuewen Yang Shisen Li Chunsheng Xu Shushang Liu Xiang Zhang Bo Lian Mengbin Li |
| author_facet | Xuewen Yang Shisen Li Chunsheng Xu Shushang Liu Xiang Zhang Bo Lian Mengbin Li |
| author_sort | Xuewen Yang |
| collection | DOAJ |
| description | We aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse tumor model. The tumor volume was then detected. sirt1 was over-expressed significantly in ESCC patients and cells. Moreover, sirt1 knockdown raised ESCC sensitivity to cisplatin. Besides, glycolysis was associated with ESCC cell chemotherapy resistance to cisplatin. Furthermore, sirt1 increased ESCC cells’ cisplatin chemosensitivity through HK2. Sirt1 enhanced in vivo ESCC chemosensitivity to cisplatin. Overall, these findings suggested that sirt1 knockdown regulated the glycolysis pathway and raised the ESCC chemotherapeutic sensitivity. |
| format | Article |
| id | doaj-art-dfa44998f9694b6ba2e85c2352a75f53 |
| institution | OA Journals |
| issn | 1538-4047 1555-8576 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cancer Biology & Therapy |
| spelling | doaj-art-dfa44998f9694b6ba2e85c2352a75f532025-08-20T02:38:14ZengTaylor & Francis GroupCancer Biology & Therapy1538-40471555-85762024-12-0125110.1080/15384047.2024.2365449Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinomaXuewen Yang0Shisen Li1Chunsheng Xu2Shushang Liu3Xiang Zhang4Bo Lian5Mengbin Li6Gastrointestinal Surgery Department, The First Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi, ChinaGastrointestinal Surgery Department, The First Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi, ChinaGastrointestinal Surgery Department, The First Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi, ChinaGastrointestinal Surgery Department, The First Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi, ChinaGastrointestinal Surgery Department, The First Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi, ChinaClinical Nutrition Department, The First Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi, ChinaGastrointestinal Surgery Department, The First Affiliated Hospital of Air Force Medical University, Xi’an, Shaanxi, ChinaWe aimed to evaluate the influence of sirtuin1 (sirt1) on the ESCC chemotherapeutic sensitivity to cisplatin. We used ESCC cell ablation sirt1 for establishing a xenograft mouse tumor model. The tumor volume was then detected. sirt1 was over-expressed significantly in ESCC patients and cells. Moreover, sirt1 knockdown raised ESCC sensitivity to cisplatin. Besides, glycolysis was associated with ESCC cell chemotherapy resistance to cisplatin. Furthermore, sirt1 increased ESCC cells’ cisplatin chemosensitivity through HK2. Sirt1 enhanced in vivo ESCC chemosensitivity to cisplatin. Overall, these findings suggested that sirt1 knockdown regulated the glycolysis pathway and raised the ESCC chemotherapeutic sensitivity.https://www.tandfonline.com/doi/10.1080/15384047.2024.2365449Esophageal squamous cell carcinomaglycolysiscisplatinchemosensitivitysirt1 |
| spellingShingle | Xuewen Yang Shisen Li Chunsheng Xu Shushang Liu Xiang Zhang Bo Lian Mengbin Li Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma Cancer Biology & Therapy Esophageal squamous cell carcinoma glycolysis cisplatin chemosensitivity sirt1 |
| title | Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma |
| title_full | Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma |
| title_fullStr | Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma |
| title_full_unstemmed | Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma |
| title_short | Sirtuin1 (sirt1) regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma |
| title_sort | sirtuin1 sirt1 regulates the glycolysis pathway and decreases cisplatin chemotherapeutic sensitivity to esophageal squamous cell carcinoma |
| topic | Esophageal squamous cell carcinoma glycolysis cisplatin chemosensitivity sirt1 |
| url | https://www.tandfonline.com/doi/10.1080/15384047.2024.2365449 |
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