Slit-Robo signaling supports motor neuron avoidance of the spinal cord midline through DCC antagonism and other mechanisms

Slit-Robo signaling supports motor neuron avoidance of the spinal cord midline through DCC antagonism and other mechanisms

Axon pathfinding and neuronal migration are orchestrated by attractive and repulsive guidance cues. In the mouse spinal cord, repulsion from Slit proteins through Robo family receptors and attraction to Netrin-1, mediated by the receptor DCC, control many aspects of neural circuit formation. This in...

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Bibliographic Details
Main Authors: Kelsey R. Nickerson, Ferass M. Sammoura, Yonghong Zhou, Alexander Jaworski
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
axon guidance
neuronal migration
spinal cord
motor neuron
robo signaling
crosstalk
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1563403/full
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