Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury.

Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury.

<h4>Rationale</h4>High-fat diet with obesity-associated co-morbidities triggers cardiac remodeling and renders the heart more vulnerable to ischemia/reperfusion injury. However, the effect of high-fat diet without obesity and associated co-morbidities is presently unknown.<h4>Objec...

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Main Authors: Ben Littlejohns, Philippe Pasdois, Simon Duggan, Andrew R Bond, Kate Heesom, Christopher L Jackson, Gianni D Angelini, Andrew P Halestrap, M-Saadeh Suleiman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0100579
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https://doi.org/10.1371/journal.pone.0100579

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