Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon
Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative str...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/9864371 |
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| author | Landry Nguepnkep Kubong Prosper Cabral Nya Biapa Bernard Chetcha Nicolas Yanou-Njintang Vicky Jocelyne Moor Ama Constant Anatole Pieme |
| author_facet | Landry Nguepnkep Kubong Prosper Cabral Nya Biapa Bernard Chetcha Nicolas Yanou-Njintang Vicky Jocelyne Moor Ama Constant Anatole Pieme |
| author_sort | Landry Nguepnkep Kubong |
| collection | DOAJ |
| description | Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. Methods. A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October 2017. After informed consent through the signature of a consent form was obtained, the plasma was collected to determine the lipid profile while the lysate solution of RBC was used to explore some markers of oxidative stress using spectrophotometric methods. Results. Among the 85 patients included in our study, the mean age was 30 ± 5 years and the female to male ratio was 0.97. The majority of the patients (52–81%) had dyslipidaemia, and 22.4% of the patients demonstrated a higher level of atherogenic index of plasma. The patients with a higher level of total cholesterol (TC) (>240 mg/dl) and low-density lipoprotein (LDL-C) (>159 mg/dl) had at least 1,334 fold of malondialdeheyde (MDA) concentration than those with normal level. Also in the same patients, the higher atherogenic plasmatic index (API) significantly (p<0.05) increased with the concentration of MDA. Except HDL-C, the other parameters of lipid profile had significant (p<0.05) correlation with reduced glutathione (GsH) and total antioxidant capacity (TAC). The significant (p<0.05) and linear regression was found between the increased MDA and higher API. Conclusion. Dyslipidemia increases oxidative stress and higher API which leads to coronary vascular disease in patients with SCA. |
| format | Article |
| id | doaj-art-df9a974db32f4908b5d0969db0d9364b |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-df9a974db32f4908b5d0969db0d9364b2025-08-20T03:26:22ZengWileyAdvances in Hematology1687-91041687-91122020-01-01202010.1155/2020/98643719864371Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in CameroonLandry Nguepnkep Kubong0Prosper Cabral Nya Biapa1Bernard Chetcha2Nicolas Yanou-Njintang3Vicky Jocelyne Moor Ama4Constant Anatole Pieme5Faculty of Sciences, University of Ngaoundere, Ngaoundere, CameroonFaculty of Sciences, University of Dschang, Dschang, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaounde, CameroonFaculty of Sciences, University of Ngaoundere, Ngaoundere, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaounde, CameroonFaculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaounde, CameroonDyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. Methods. A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October 2017. After informed consent through the signature of a consent form was obtained, the plasma was collected to determine the lipid profile while the lysate solution of RBC was used to explore some markers of oxidative stress using spectrophotometric methods. Results. Among the 85 patients included in our study, the mean age was 30 ± 5 years and the female to male ratio was 0.97. The majority of the patients (52–81%) had dyslipidaemia, and 22.4% of the patients demonstrated a higher level of atherogenic index of plasma. The patients with a higher level of total cholesterol (TC) (>240 mg/dl) and low-density lipoprotein (LDL-C) (>159 mg/dl) had at least 1,334 fold of malondialdeheyde (MDA) concentration than those with normal level. Also in the same patients, the higher atherogenic plasmatic index (API) significantly (p<0.05) increased with the concentration of MDA. Except HDL-C, the other parameters of lipid profile had significant (p<0.05) correlation with reduced glutathione (GsH) and total antioxidant capacity (TAC). The significant (p<0.05) and linear regression was found between the increased MDA and higher API. Conclusion. Dyslipidemia increases oxidative stress and higher API which leads to coronary vascular disease in patients with SCA.http://dx.doi.org/10.1155/2020/9864371 |
| spellingShingle | Landry Nguepnkep Kubong Prosper Cabral Nya Biapa Bernard Chetcha Nicolas Yanou-Njintang Vicky Jocelyne Moor Ama Constant Anatole Pieme Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon Advances in Hematology |
| title | Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon |
| title_full | Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon |
| title_fullStr | Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon |
| title_full_unstemmed | Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon |
| title_short | Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon |
| title_sort | relationship between higher atherogenic index of plasma and oxidative stress of a group of patients living with sickle cell anemia in cameroon |
| url | http://dx.doi.org/10.1155/2020/9864371 |
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