Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to Recanalization
Background Data on treating idiopathic portal vein thrombosis (IPVT)—via anticoagulation (AC), systemic thrombolysis (ST), endovascular intervention (EVI), and surgery—are limited, despite the potentially severe clinical implications of this condition. This study aims to compare treatment outcomes a...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-08-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296251368885 |
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| author | Xiaolu Zhu MS Zhize Peng MS Yinjun Xu MS Yuanqiang Lu PhD |
| author_facet | Xiaolu Zhu MS Zhize Peng MS Yinjun Xu MS Yuanqiang Lu PhD |
| author_sort | Xiaolu Zhu MS |
| collection | DOAJ |
| description | Background Data on treating idiopathic portal vein thrombosis (IPVT)—via anticoagulation (AC), systemic thrombolysis (ST), endovascular intervention (EVI), and surgery—are limited, despite the potentially severe clinical implications of this condition. This study aims to compare treatment outcomes and evaluate the prognosis. Methods A retrospective analysis of 77 IPVT patients was conducted. Patients were categorized according to their treatment modalities, and their demographics, clinical features, prognoses, and risk factors were analyzed. The primary endpoint was the radiological complete recanalization (CR) rate; secondary endpoints were clinical portal hypertension (CPH) incidence and overall mortality. Results Among the 77 patients with IPVT included in this study, 26 received AC, 23 EVI, 17 ST, and 11 surgery. During follow-up, the overall CR rate was 23.4%, CPH incidence 14.3%, and mortality 7.8%. Patients treated with EVI had a significantly higher CR rate than AC patients (HR: 0.214, 95%CI: 0.058 - 0.795, P = .011). Treatment modalities had no significant impact on long-term survival or CPH. Cox regression analysis identified elevated C-reactive protein (CRP) levels (HR 1.045, 95%CI: 1.016 - 1.075, P = .002) and splenomegaly (HR 20.325, 95%CI: 1.952 - 212.213, P = .012) at admission as mortality risk factors. Conclusions EVI therapy enhances the CR rate in IPVT patients compared to anticoagulation alone. Elevated CRP and splenomegaly at admission independently increase IPVT mortality. |
| format | Article |
| id | doaj-art-df917fcc76294c2ba69cbfb25596bfac |
| institution | Kabale University |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-df917fcc76294c2ba69cbfb25596bfac2025-08-20T04:03:13ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-08-013110.1177/10760296251368885Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to RecanalizationXiaolu Zhu MS0Zhize Peng MS1Yinjun Xu MS2Yuanqiang Lu PhD3 Department of Emergency, , Hangzhou, China Department of Emergency, , Hangzhou, China Department of Emergency, the First People's Hospital of Lin’an District, Hangzhou, China Department of Emergency, , Hangzhou, ChinaBackground Data on treating idiopathic portal vein thrombosis (IPVT)—via anticoagulation (AC), systemic thrombolysis (ST), endovascular intervention (EVI), and surgery—are limited, despite the potentially severe clinical implications of this condition. This study aims to compare treatment outcomes and evaluate the prognosis. Methods A retrospective analysis of 77 IPVT patients was conducted. Patients were categorized according to their treatment modalities, and their demographics, clinical features, prognoses, and risk factors were analyzed. The primary endpoint was the radiological complete recanalization (CR) rate; secondary endpoints were clinical portal hypertension (CPH) incidence and overall mortality. Results Among the 77 patients with IPVT included in this study, 26 received AC, 23 EVI, 17 ST, and 11 surgery. During follow-up, the overall CR rate was 23.4%, CPH incidence 14.3%, and mortality 7.8%. Patients treated with EVI had a significantly higher CR rate than AC patients (HR: 0.214, 95%CI: 0.058 - 0.795, P = .011). Treatment modalities had no significant impact on long-term survival or CPH. Cox regression analysis identified elevated C-reactive protein (CRP) levels (HR 1.045, 95%CI: 1.016 - 1.075, P = .002) and splenomegaly (HR 20.325, 95%CI: 1.952 - 212.213, P = .012) at admission as mortality risk factors. Conclusions EVI therapy enhances the CR rate in IPVT patients compared to anticoagulation alone. Elevated CRP and splenomegaly at admission independently increase IPVT mortality.https://doi.org/10.1177/10760296251368885 |
| spellingShingle | Xiaolu Zhu MS Zhize Peng MS Yinjun Xu MS Yuanqiang Lu PhD Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to Recanalization Clinical and Applied Thrombosis/Hemostasis |
| title | Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to Recanalization |
| title_full | Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to Recanalization |
| title_fullStr | Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to Recanalization |
| title_full_unstemmed | Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to Recanalization |
| title_short | Idiopathic Portal Vein Thrombosis: Endovascular Intervention Leads the Way to Recanalization |
| title_sort | idiopathic portal vein thrombosis endovascular intervention leads the way to recanalization |
| url | https://doi.org/10.1177/10760296251368885 |
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