Global research trends and emerging hotspots of RNF213 in Moyamoya disease: A bibliometric analysis (2011–2024)
Background: Moyamoya disease (MMD) is a rare, chronic cerebrovascular disorder characterized by progressive stenosis of the internal carotid arteries and the development of collateral vascular networks. Recent research has increasingly focused on the RNF213 gene to better understand its role in the...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-10-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025003016 |
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| Summary: | Background: Moyamoya disease (MMD) is a rare, chronic cerebrovascular disorder characterized by progressive stenosis of the internal carotid arteries and the development of collateral vascular networks. Recent research has increasingly focused on the RNF213 gene to better understand its role in the pathophysiology of MMD. This study aims to assess global research trends, identify key contributors, and explore emerging research hotspots related to RNF213 and MMD. Methods: A bibliometric analysis was performed on publications from 2011 to 2024, retrieved from the Web of Science Core Collection database. Data were analyzed and visualized using VOSviewer 1.6.20, CiteSpace 6.3.R1, and R 4.3.3. Results: A total of 356 publications were identified, showing a rapid annual growth rate of 27.06 %. Japan was the leading country in both publication output (137 publications) and citations (4288 citations). Prominent institutions included Kyoto University (88 publications) and Tohoku University (65 publications). The journal Stroke had the highest citation impact (1318 citations). Notable authors included Koizumi Akio (30 publications, 1726 citations) and Fujimura Miki (28 publications, 1422 citations). The term ''variant'' highlights the growing interest in genetic diversity, while ''vascular disorders'' reflects an increasing focus on the vascular components and pathological mechanisms of the disease. Conclusion: This bibliometric analysis underscores significant progress in understanding the genetic mechanisms and clinical features of MMD, particularly with regard to vascular issues and disease onset. Future research should incorporate multi-database analyses and expand the range of document types to offer a more comprehensive understanding of this evolving field. |
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| ISSN: | 1873-2747 |