Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review
Background: Malignant potential of Oral Lichen Planus (OLP) is underestimated and given less importance. Only few studies were noted explaining the pathogenesis involved in its cancer progression. Aim: The aim of the study is to bring in a spotlight for masquerading the role of TGF-β by determining...
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| Language: | English |
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004485 |
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| author | Harinisubasri M Priyadharsini Nataraj Dineshkumar Thayalan Divya Bose Rameshkumar Annasamy Rajkumar K |
| author_facet | Harinisubasri M Priyadharsini Nataraj Dineshkumar Thayalan Divya Bose Rameshkumar Annasamy Rajkumar K |
| author_sort | Harinisubasri M |
| collection | DOAJ |
| description | Background: Malignant potential of Oral Lichen Planus (OLP) is underestimated and given less importance. Only few studies were noted explaining the pathogenesis involved in its cancer progression. Aim: The aim of the study is to bring in a spotlight for masquerading the role of TGF-β by determining its expression using immunohistochemistry in the malignant transformation of oral lichen planus. Materials and methods: This systematic review followed PRISMA guidelines and criteria. Electronic literature searches were carried out in databases MEDLINE (via PubMed) and Google Scholar to identify studies that matched the following MESH Terms (Expression AND TGF-β AND oral lichen planus) for identifying articles published between 2008 t0 2021. Manually searched for the references and citations of the identified articles for further research studies. Results: All the articles included in this study included TGF-β and its related protein expression in both its pathogenesis and cancer growth.This help to bring in newer and targeted treated options. Conclusion: Role of TGF in lichen planus was briefly studied and it was concluded that TGF-β played a major role in its malignant transformation. To discover the role TGFβ in the maintenance of chronic tonicity of the disease and thereby unmasking its function in malignant transformation of OLP a systematic review is done. This systematic review accumulates all the possible effects of TGF-β in malignant transformation of oral lichen planus. So thereby it helps in developing novel targeted therapy to shield the lesion from its carcinomatous transformation. |
| format | Article |
| id | doaj-art-df8c625cf75048d9815d5e1d1fe37aac |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-df8c625cf75048d9815d5e1d1fe37aac2025-01-09T06:16:53ZengElsevierOral Oncology Reports2772-90602024-09-0111100602Expression of TGF-β in malignant transformation of oral lichen planus - A systematic reviewHarinisubasri M0Priyadharsini Nataraj1Dineshkumar Thayalan2Divya Bose3Rameshkumar Annasamy4Rajkumar K5Department of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, IndiaCorresponding author.; Department of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, IndiaDepartment of Oral Pathology & Microbiology, SRM Dental College, Bharathi Salai, Ramapuram, Chennai, IndiaBackground: Malignant potential of Oral Lichen Planus (OLP) is underestimated and given less importance. Only few studies were noted explaining the pathogenesis involved in its cancer progression. Aim: The aim of the study is to bring in a spotlight for masquerading the role of TGF-β by determining its expression using immunohistochemistry in the malignant transformation of oral lichen planus. Materials and methods: This systematic review followed PRISMA guidelines and criteria. Electronic literature searches were carried out in databases MEDLINE (via PubMed) and Google Scholar to identify studies that matched the following MESH Terms (Expression AND TGF-β AND oral lichen planus) for identifying articles published between 2008 t0 2021. Manually searched for the references and citations of the identified articles for further research studies. Results: All the articles included in this study included TGF-β and its related protein expression in both its pathogenesis and cancer growth.This help to bring in newer and targeted treated options. Conclusion: Role of TGF in lichen planus was briefly studied and it was concluded that TGF-β played a major role in its malignant transformation. To discover the role TGFβ in the maintenance of chronic tonicity of the disease and thereby unmasking its function in malignant transformation of OLP a systematic review is done. This systematic review accumulates all the possible effects of TGF-β in malignant transformation of oral lichen planus. So thereby it helps in developing novel targeted therapy to shield the lesion from its carcinomatous transformation.http://www.sciencedirect.com/science/article/pii/S2772906024004485Oral lichen planusPremalignancyTransforming growth factor betaImmunohistochemistry |
| spellingShingle | Harinisubasri M Priyadharsini Nataraj Dineshkumar Thayalan Divya Bose Rameshkumar Annasamy Rajkumar K Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review Oral Oncology Reports Oral lichen planus Premalignancy Transforming growth factor beta Immunohistochemistry |
| title | Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review |
| title_full | Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review |
| title_fullStr | Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review |
| title_full_unstemmed | Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review |
| title_short | Expression of TGF-β in malignant transformation of oral lichen planus - A systematic review |
| title_sort | expression of tgf β in malignant transformation of oral lichen planus a systematic review |
| topic | Oral lichen planus Premalignancy Transforming growth factor beta Immunohistochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004485 |
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