Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy

PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, PANoptosis is involved in multiple cell death pathways that affect tumor cell survival, proliferation, and response to treatment, serving as an innovative strategy for cancer therapy. Endocrin...

Full description

Saved in:
Bibliographic Details
Main Authors: Li Wang, Baisheng Lin, Feixiang Wang, Zili Dai, Guofeng Xie, Jian Zhang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325000144
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832590994309120000
author Li Wang
Baisheng Lin
Feixiang Wang
Zili Dai
Guofeng Xie
Jian Zhang
author_facet Li Wang
Baisheng Lin
Feixiang Wang
Zili Dai
Guofeng Xie
Jian Zhang
author_sort Li Wang
collection DOAJ
description PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, PANoptosis is involved in multiple cell death pathways that affect tumor cell survival, proliferation, and response to treatment, serving as an innovative strategy for cancer therapy. Endocrine-disrupting chemicals (EDCs) impact the endocrine system, including cancer. However, research on their influence on head and neck carcinoma (HNSC) through PANoptosis genes remains limited. This study utilises transcriptomic and clinical data related to HNSC from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. We developed a risk model based on PANoptosis-related genes through LASSO Cox regression analysis. Finally, we utilized a Sankey diagram to depict the relationships between EDCs and key genes, identifying DSCAM, IL-6, and SYCP2 as critical predictors of HNSC PANoptosis. These essential genes identified 214 EDCs potentially influencing HNSC, including 3 (Aroclor 1242, Pentachlorobenzene, and Propanil) previously unreported to HNSC. These findings elucidate novel relationships between PANoptosis-related genes mediated by EDCs and the pathogenesis of HNSC.
format Article
id doaj-art-df8c0e9ff044488aa128724e35118dc3
institution Kabale University
issn 0147-6513
language English
publishDate 2025-01-01
publisher Elsevier
record_format Article
series Ecotoxicology and Environmental Safety
spelling doaj-art-df8c0e9ff044488aa128724e35118dc32025-01-23T05:26:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117678Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapyLi Wang0Baisheng Lin1Feixiang Wang2Zili Dai3Guofeng Xie4Jian Zhang5Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thoracic Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China; Corresponding authors.Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China; Corresponding authors.PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, PANoptosis is involved in multiple cell death pathways that affect tumor cell survival, proliferation, and response to treatment, serving as an innovative strategy for cancer therapy. Endocrine-disrupting chemicals (EDCs) impact the endocrine system, including cancer. However, research on their influence on head and neck carcinoma (HNSC) through PANoptosis genes remains limited. This study utilises transcriptomic and clinical data related to HNSC from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. We developed a risk model based on PANoptosis-related genes through LASSO Cox regression analysis. Finally, we utilized a Sankey diagram to depict the relationships between EDCs and key genes, identifying DSCAM, IL-6, and SYCP2 as critical predictors of HNSC PANoptosis. These essential genes identified 214 EDCs potentially influencing HNSC, including 3 (Aroclor 1242, Pentachlorobenzene, and Propanil) previously unreported to HNSC. These findings elucidate novel relationships between PANoptosis-related genes mediated by EDCs and the pathogenesis of HNSC.http://www.sciencedirect.com/science/article/pii/S0147651325000144PANoptosisHead and neck cancerEndocrine-disrupting chemicalsTumor microenvironmentImmunotherapy
spellingShingle Li Wang
Baisheng Lin
Feixiang Wang
Zili Dai
Guofeng Xie
Jian Zhang
Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
Ecotoxicology and Environmental Safety
PANoptosis
Head and neck cancer
Endocrine-disrupting chemicals
Tumor microenvironment
Immunotherapy
title Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
title_full Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
title_fullStr Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
title_full_unstemmed Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
title_short Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
title_sort exploring panoptosis in head and neck cancer a novel approach to cancer therapy
topic PANoptosis
Head and neck cancer
Endocrine-disrupting chemicals
Tumor microenvironment
Immunotherapy
url http://www.sciencedirect.com/science/article/pii/S0147651325000144
work_keys_str_mv AT liwang exploringpanoptosisinheadandneckcanceranovelapproachtocancertherapy
AT baishenglin exploringpanoptosisinheadandneckcanceranovelapproachtocancertherapy
AT feixiangwang exploringpanoptosisinheadandneckcanceranovelapproachtocancertherapy
AT zilidai exploringpanoptosisinheadandneckcanceranovelapproachtocancertherapy
AT guofengxie exploringpanoptosisinheadandneckcanceranovelapproachtocancertherapy
AT jianzhang exploringpanoptosisinheadandneckcanceranovelapproachtocancertherapy