Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy
PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, PANoptosis is involved in multiple cell death pathways that affect tumor cell survival, proliferation, and response to treatment, serving as an innovative strategy for cancer therapy. Endocrin...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000144 |
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| author | Li Wang Baisheng Lin Feixiang Wang Zili Dai Guofeng Xie Jian Zhang |
| author_facet | Li Wang Baisheng Lin Feixiang Wang Zili Dai Guofeng Xie Jian Zhang |
| author_sort | Li Wang |
| collection | DOAJ |
| description | PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, PANoptosis is involved in multiple cell death pathways that affect tumor cell survival, proliferation, and response to treatment, serving as an innovative strategy for cancer therapy. Endocrine-disrupting chemicals (EDCs) impact the endocrine system, including cancer. However, research on their influence on head and neck carcinoma (HNSC) through PANoptosis genes remains limited. This study utilises transcriptomic and clinical data related to HNSC from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. We developed a risk model based on PANoptosis-related genes through LASSO Cox regression analysis. Finally, we utilized a Sankey diagram to depict the relationships between EDCs and key genes, identifying DSCAM, IL-6, and SYCP2 as critical predictors of HNSC PANoptosis. These essential genes identified 214 EDCs potentially influencing HNSC, including 3 (Aroclor 1242, Pentachlorobenzene, and Propanil) previously unreported to HNSC. These findings elucidate novel relationships between PANoptosis-related genes mediated by EDCs and the pathogenesis of HNSC. |
| format | Article |
| id | doaj-art-df8c0e9ff044488aa128724e35118dc3 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-df8c0e9ff044488aa128724e35118dc32025-01-23T05:26:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117678Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapyLi Wang0Baisheng Lin1Feixiang Wang2Zili Dai3Guofeng Xie4Jian Zhang5Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thoracic Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China; Corresponding authors.Department of Radiation Oncology, Guangzhou Institute of Cancer Research, the Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, China; Corresponding authors.PANoptosis is a newly discovered complex programmed cell death (PCD) form. In the field of cancer research, PANoptosis is involved in multiple cell death pathways that affect tumor cell survival, proliferation, and response to treatment, serving as an innovative strategy for cancer therapy. Endocrine-disrupting chemicals (EDCs) impact the endocrine system, including cancer. However, research on their influence on head and neck carcinoma (HNSC) through PANoptosis genes remains limited. This study utilises transcriptomic and clinical data related to HNSC from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. We developed a risk model based on PANoptosis-related genes through LASSO Cox regression analysis. Finally, we utilized a Sankey diagram to depict the relationships between EDCs and key genes, identifying DSCAM, IL-6, and SYCP2 as critical predictors of HNSC PANoptosis. These essential genes identified 214 EDCs potentially influencing HNSC, including 3 (Aroclor 1242, Pentachlorobenzene, and Propanil) previously unreported to HNSC. These findings elucidate novel relationships between PANoptosis-related genes mediated by EDCs and the pathogenesis of HNSC.http://www.sciencedirect.com/science/article/pii/S0147651325000144PANoptosisHead and neck cancerEndocrine-disrupting chemicalsTumor microenvironmentImmunotherapy |
| spellingShingle | Li Wang Baisheng Lin Feixiang Wang Zili Dai Guofeng Xie Jian Zhang Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy Ecotoxicology and Environmental Safety PANoptosis Head and neck cancer Endocrine-disrupting chemicals Tumor microenvironment Immunotherapy |
| title | Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy |
| title_full | Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy |
| title_fullStr | Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy |
| title_full_unstemmed | Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy |
| title_short | Exploring PANoptosis in head and neck cancer: A novel approach to cancer therapy |
| title_sort | exploring panoptosis in head and neck cancer a novel approach to cancer therapy |
| topic | PANoptosis Head and neck cancer Endocrine-disrupting chemicals Tumor microenvironment Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000144 |
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