EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITIS
The results of the open controlled prospective clinical and immunological trial indicate that including of pidotimod into the complex therapy of pyelonephritis in children (n=30) lead to reliable decrease of recurrence risk and frequency during 6 months after treatment withdrawal in comparison with...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2013-02-01
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| Series: | Вопросы современной педиатрии |
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| Online Access: | https://vsp.spr-journal.ru/jour/article/view/367 |
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| _version_ | 1849409926057689088 |
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| author | V. I. Kirillov O. V. Zaitseva N. A. Bogdanova |
| author_facet | V. I. Kirillov O. V. Zaitseva N. A. Bogdanova |
| author_sort | V. I. Kirillov |
| collection | DOAJ |
| description | The results of the open controlled prospective clinical and immunological trial indicate that including of pidotimod into the complex therapy of pyelonephritis in children (n=30) lead to reliable decrease of recurrence risk and frequency during 6 months after treatment withdrawal in comparison with children receiving antibacterial monotherapy (n=20). The duration of etiotropic treatment for arresting of the active manifestations of urinary tract infection was lower in patients who were administered the afore-mentioned drug. Immunological monitoring of the urine cytokine status during pidotimod treatment showed that there were signs of T helper 1 cells activation predominance (increase in interferon/interleukin 10 ratio), as well as decrease in granulocyte macrophage colony-stimulating factor concentration, which seems to cause the delayed influence of the drug on the course of urinary tract infection. |
| format | Article |
| id | doaj-art-df85183f5f86434f8d7b1ee7b2bd4607 |
| institution | Kabale University |
| issn | 1682-5527 1682-5535 |
| language | English |
| publishDate | 2013-02-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj-art-df85183f5f86434f8d7b1ee7b2bd46072025-08-20T03:35:19Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352013-02-01121242910.15690/vsp.v12i1.555367EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITISV. I. Kirillov0O. V. Zaitseva1N. A. Bogdanova2Moscow State University of Medicine and Dentistry named after A.I. EvdokimovMoscow State University of Medicine and Dentistry named after A.I. EvdokimovMoscow State University of Medicine and Dentistry named after A.I. EvdokimovThe results of the open controlled prospective clinical and immunological trial indicate that including of pidotimod into the complex therapy of pyelonephritis in children (n=30) lead to reliable decrease of recurrence risk and frequency during 6 months after treatment withdrawal in comparison with children receiving antibacterial monotherapy (n=20). The duration of etiotropic treatment for arresting of the active manifestations of urinary tract infection was lower in patients who were administered the afore-mentioned drug. Immunological monitoring of the urine cytokine status during pidotimod treatment showed that there were signs of T helper 1 cells activation predominance (increase in interferon/interleukin 10 ratio), as well as decrease in granulocyte macrophage colony-stimulating factor concentration, which seems to cause the delayed influence of the drug on the course of urinary tract infection.https://vsp.spr-journal.ru/jour/article/view/367childrenpidotimodpyelonephritiscytokines |
| spellingShingle | V. I. Kirillov O. V. Zaitseva N. A. Bogdanova EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITIS Вопросы современной педиатрии children pidotimod pyelonephritis cytokines |
| title | EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITIS |
| title_full | EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITIS |
| title_fullStr | EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITIS |
| title_full_unstemmed | EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITIS |
| title_short | EFFICACY OF IMMUNOCORRECTIVE TREATMENT WITH SYNTHETIC DIPEPTIDE IN CHILDREN WITH PYELONEPHRITIS |
| title_sort | efficacy of immunocorrective treatment with synthetic dipeptide in children with pyelonephritis |
| topic | children pidotimod pyelonephritis cytokines |
| url | https://vsp.spr-journal.ru/jour/article/view/367 |
| work_keys_str_mv | AT vikirillov efficacyofimmunocorrectivetreatmentwithsyntheticdipeptideinchildrenwithpyelonephritis AT ovzaitseva efficacyofimmunocorrectivetreatmentwithsyntheticdipeptideinchildrenwithpyelonephritis AT nabogdanova efficacyofimmunocorrectivetreatmentwithsyntheticdipeptideinchildrenwithpyelonephritis |