The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC
Background. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its adjacent tissues. Statistical analysis was done by...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2022/9651503 |
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| author | Yan Shi Meng-Yan Li Hui Wang Chao Li Wen-Ying Liu Yong-Mei Gao Bo Wang Jia-Wei Song Yu-Qing Ma |
| author_facet | Yan Shi Meng-Yan Li Hui Wang Chao Li Wen-Ying Liu Yong-Mei Gao Bo Wang Jia-Wei Song Yu-Qing Ma |
| author_sort | Yan Shi |
| collection | DOAJ |
| description | Background. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its adjacent tissues. Statistical analysis was done by SPSS 23.0. Results. The high expression of MACC1 and cyclin D1 was significantly correlated with tumor size. High c-Met expression was associated with patient ethnicity. MACC1 expression was positively correlated with both c-Met and cyclin D1. c-Met expression was also positively correlated with cyclin D1. Patients with high expression of MACC1 and c-Met had worse OS; patients with high c-Met expression also had worse PFS. Conclusion. MACC1, c-Met, and cyclin D1 proteins are closely related to the occurrence and development of esophageal squamous cell carcinoma. MACC1 may affect the prognosis of ESCC by regulating the expression of the c-Met/cyclin D1 axis. |
| format | Article |
| id | doaj-art-df837716fced47e18200b610551d07ec |
| institution | OA Journals |
| issn | 2210-7185 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-df837716fced47e18200b610551d07ec2025-08-20T02:21:09ZengWileyAnalytical Cellular Pathology2210-71852022-01-01202210.1155/2022/9651503The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCCYan Shi0Meng-Yan Li1Hui Wang2Chao Li3Wen-Ying Liu4Yong-Mei Gao5Bo Wang6Jia-Wei Song7Yu-Qing Ma8Department of PathologyDepartment of PathologyDepartment of PathologyDepartment of RICUDepartment of PathologyDepartment of PathologyDepartment of PathologyXi’an Medical UniversityDepartment of PathologyBackground. Esophageal cancer is one of the most common malignant tumors of the digestive system, with high incidence and mortality. Methods. Immunohistochemical method was used to detect the expression of MACC1, c-Met, and cyclin D1 in ESCC and its adjacent tissues. Statistical analysis was done by SPSS 23.0. Results. The high expression of MACC1 and cyclin D1 was significantly correlated with tumor size. High c-Met expression was associated with patient ethnicity. MACC1 expression was positively correlated with both c-Met and cyclin D1. c-Met expression was also positively correlated with cyclin D1. Patients with high expression of MACC1 and c-Met had worse OS; patients with high c-Met expression also had worse PFS. Conclusion. MACC1, c-Met, and cyclin D1 proteins are closely related to the occurrence and development of esophageal squamous cell carcinoma. MACC1 may affect the prognosis of ESCC by regulating the expression of the c-Met/cyclin D1 axis.http://dx.doi.org/10.1155/2022/9651503 |
| spellingShingle | Yan Shi Meng-Yan Li Hui Wang Chao Li Wen-Ying Liu Yong-Mei Gao Bo Wang Jia-Wei Song Yu-Qing Ma The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC Analytical Cellular Pathology |
| title | The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC |
| title_full | The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC |
| title_fullStr | The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC |
| title_full_unstemmed | The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC |
| title_short | The Relationship between MACC1/c-Met/Cyclin D1 Axis Expression and Prognosis in ESCC |
| title_sort | relationship between macc1 c met cyclin d1 axis expression and prognosis in escc |
| url | http://dx.doi.org/10.1155/2022/9651503 |
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