Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT
The carboxylic acid group of ciprofloxacin was modified and amino mercapto triazole was substituted. The compound was confirmed by physical parameters (solubility, melting point), chromatographic methods (TLC) and consistent with its IR & 1HNMR spectra. The synthesized analogue was screened for...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/340451 |
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| author | S. Jubie R. Kalirajan Pavankumar Yadav |
| author_facet | S. Jubie R. Kalirajan Pavankumar Yadav |
| author_sort | S. Jubie |
| collection | DOAJ |
| description | The carboxylic acid group of ciprofloxacin was modified and amino mercapto triazole was substituted. The compound was confirmed by physical parameters (solubility, melting point), chromatographic methods (TLC) and consistent with its IR & 1HNMR spectra. The synthesized analogue was screened for antibacterial activity against one gram positive & two gram negative species. The compound exhibited good antibacterial effect towards gram negative species when compared to the standard ciprofloxacin. At the same time the analogue was retaining antibacterial activity towards gram positive species when compared to standard ciprofloxacin. The molecular docking studies showed a good correlation between their antibacterial activity and autodock binding free energy. |
| format | Article |
| id | doaj-art-df824ae97b8445ae854bb7ce40e6a7d1 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-df824ae97b8445ae854bb7ce40e6a7d12025-08-20T03:26:22ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-019298098710.1155/2012/340451Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENTS. Jubie0R. Kalirajan1Pavankumar Yadav2Department of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, off campus - JSS University, Mysore, IndiaDepartment of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, off campus - JSS University, Mysore, IndiaDepartment of Pharmaceutical Chemistry, J.S.S. College of Pharmacy, off campus - JSS University, Mysore, IndiaThe carboxylic acid group of ciprofloxacin was modified and amino mercapto triazole was substituted. The compound was confirmed by physical parameters (solubility, melting point), chromatographic methods (TLC) and consistent with its IR & 1HNMR spectra. The synthesized analogue was screened for antibacterial activity against one gram positive & two gram negative species. The compound exhibited good antibacterial effect towards gram negative species when compared to the standard ciprofloxacin. At the same time the analogue was retaining antibacterial activity towards gram positive species when compared to standard ciprofloxacin. The molecular docking studies showed a good correlation between their antibacterial activity and autodock binding free energy.http://dx.doi.org/10.1155/2012/340451 |
| spellingShingle | S. Jubie R. Kalirajan Pavankumar Yadav Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT E-Journal of Chemistry |
| title | Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT |
| title_full | Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT |
| title_fullStr | Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT |
| title_full_unstemmed | Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT |
| title_short | Design, Synthesis and Docking Studies of a Novel Ciprofloxacin Analogue as an Antimicrobial AGENT |
| title_sort | design synthesis and docking studies of a novel ciprofloxacin analogue as an antimicrobial agent |
| url | http://dx.doi.org/10.1155/2012/340451 |
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