Identification of Novel Risk Variants of Inflammatory Factors Related to Myeloproliferative Neoplasm: A Bidirectional Mendelian Randomization Study

Identification of Novel Risk Variants of Inflammatory Factors Related to Myeloproliferative Neoplasm: A Bidirectional Mendelian Randomization Study

Epidemiological and experimental evidence has linked chronic inflammation to the etiology of myeloproliferative neoplasm (MPN). However, it remains unclear whether genetic associations with specific inflammatory biomarkers are causal or due to bias. This study aimed to assess the effect of C-reactiv...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yang Li, Ting Sun, Jia Chen, Lei Zhang
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2024-01-01
Series:	Global Medical Genetics
Subjects:	myeloproliferative neoplasms inflammatory regulators bidirectional Mendelian randomization
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1779665
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

CHRONIC MYELOPROLIFERATIVE NEOPLASMS: A COLLABORATIVE APPROACH
by: Paola Guglielmelli, et al.
Published: (2010-05-01)

Association of modifiable risk factors and telomere length with five neuroendocrine neoplasms: a bidirectional Mendelian randomization study
by: Xujia Li, et al.
Published: (2025-05-01)

Circulating inflammatory cytokines and the risk of myasthenia gravis: a bidirectional Mendelian randomization study
by: Boyang Su, et al.
Published: (2025-07-01)

Assessing the associations of inflammatory bowel disease and hepatitis B virus infections with two-sample bidirectional mendelian randomization
by: Ping Han, et al.
Published: (2024-12-01)

Bidirectional two-sample Mendelian randomization analysis unveils causal association between inflammatory cytokines and the risk of diabetic nephropathy
by: Siyuan Song, et al.
Published: (2024-10-01)

HMGB1 as a biomarker for myeloproliferative neoplasm complicated with atherosclerosis
by: Lunbi Wu, et al.
Published: (2025-05-01)

Characteristics of regional epidemiological indicators of chronic myeloproliferative neoplasms
by: O. Yu. Vinogradova, et al.
Published: (2025-05-01)

Real-world status of treatment for lymphoid neoplasms developed during the course of myeloproliferative neoplasms in Japan
by: Yoko Edahiro, et al.
Published: (2024-12-01)

The causal impact of bioavailable testosterone levels on osteoarthritis: a bidirectional Mendelian randomized study
by: Zong Jiang, et al.
Published: (2025-04-01)

MERGE: A Multinational, Multicenter Observational Registry for Myeloproliferative Neoplasms in Asia, including Middle East, Turkey, and Algeria
by: Mohamed A. Yassin, et al.
Published: (2020-07-01)

Unraveling the impact of lysosomal dysfunction on myeloproliferative neoplasm
by: Hyundong Yoon, et al.
Published: (2024-09-01)

Systemic Inflammatory Factors and Neuropsychiatric Disorders: A Bidirectional Mendelian Randomization Study
by: Hao Wang, et al.
Published: (2025-04-01)

Application of heteroduplex analysis for CALR mutation screening detection in patients with Ph-myeloproliferative neoplasms
by: T. N. Subbotina, et al.
Published: (2021-06-01)

Dietary intake and five types of mental disorders: a bidirectional Mendelian randomization study
by: Yichun Zhang, et al.
Published: (2025-07-01)

Genomic profile helps to predict the clonal evolution and outcome of BCR-ABL-negative myeloproliferative neoplasms
by: Xiaodong Guo, et al.
Published: (2025-08-01)

Causal Relationship Between Electrocardiogram Parameters and Brugada Syndrome: A Bidirectional Mendelian Randomization Study
by: Songcui Shen, et al.
Published: (2025-03-01)

A Dual-Feature Framework for Enhanced Diagnosis of Myeloproliferative Neoplasm Subtypes Using Artificial Intelligence
by: Amna Bamaqa, et al.
Published: (2025-06-01)

The causal relationship between inflammatory cytokines and lung cancer: a two-sample bidirectional mendelian randomization study
by: Kaiyang Zhao, et al.
Published: (2025-08-01)

The causal relationship between gut microbiota and gouty nephropathy based on two-sample bidirectional Mendelian randomization
by: Xiao Mei-di, et al.
Published: (2025-07-01)

Unveiling the influence of lipidomes on inflammatory bowel disease: a bidirectional mendelian randomization study
by: Hang Lei, et al.
Published: (2025-04-01)

Myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia
by: M B Agarwal, et al.
Published: (2015-01-01)

Investigating the causal links between inflammatory cytokines and scoliosis through bidirectional Mendelian randomization analysis
by: Muradil Mardan, et al.
Published: (2024-12-01)

A Study on the Role of Thrombophilic Genetic Disorders as a Risk Factor for Thrombotic Complications in Patients with Myeloproliferative Disorders
by: Doroteya Todorieva-Todorova, et al.
Published: (2019-08-01)

Clinicopathological spectrum of BCR-ABL-Negative myeloproliferative neoplasms with correlation with janus-associated kinase 2 mutation
by: Roopa Dixith, et al.
Published: (2019-01-01)

DNA Methylation in Ph-Negative Myeloproliferative Neoplasms: Prognostic Role and Therapeutic Implications
by: Paola Barone, et al.
Published: (2025-03-01)

Not just for mature audiences: myeloproliferative neoplasms in children, adolescents, and young adults
by: Linda Resar, et al.
Published: (2025-05-01)

USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy
by: Wenjun Wang, et al.
Published: (2025-07-01)

Biology of Myeloproliferative Malignancies
by: AL Melikyan, et al.
Published: (2016-07-01)

The characteristics of CALR mutations in myeloproliferative neoplasms: a clinical experience from a tertiary care center in Qatar and a literature review
by: Mostafa Najim, et al.
Published: (2024-12-01)

The relationship between inflammatory factors and heart failure: evidence based on bidirectional Mendelian randomization analysis
by: Xuanchun Huang, et al.
Published: (2024-12-01)

Association between JAK2V617F Mutation and Mean Platelet Volume among Myeloproliferative Neoplasm Patients
by: Mushtaq M. Khazeem, et al.
Published: (2025-04-01)

Revised myeloproliferative neoplasms working group consensus recommendations for diagnosis and management of primary myelofibrosis, polycythemia vera, and essential thrombocythemia
by: Mohan B Agarwal, et al.
Published: (2018-01-01)

Exploring Bidirectional Causality between Obstructive Sleep Apnea and Chronic Kidney Disease via Mendelian Randomization
by: Liu X, et al.
Published: (2025-06-01)

Causal relationship between inflammatory cytokines and polycystic ovary syndrome: a bidirectional mendelian randomization study
by: Danling Tian, et al.
Published: (2024-11-01)

Elucidating the causal relationship between gut microbiota, metabolites, and diabetic nephropathy in European patients: Revelations from genome-wide bidirectional mendelian randomization analysis
by: Siyuan Song, et al.
Published: (2025-01-01)

The role of mitochondrial DNA copy number in female infertility: a bidirectional two-sample Mendelian randomization study
by: XiaoJu Wan, et al.
Published: (2024-12-01)

The Causal Correlation Between Gastroesophageal Reflux Disease and Chronic Widespread Pain: A Bidirectional Mendelian Randomization Study
by: Chen M, et al.
Published: (2025-06-01)

Causal association of peripheral immune cell counts with risk of prostate cancer: insights from bidirectional Mendelian randomization
by: Xiaolu Ren, et al.
Published: (2024-11-01)

Leveraging big data and artificial intelligence for smarter trials in myeloproliferative neoplasms
by: Joshua W. Bliss, et al.
Published: (2024-12-01)

Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome—insights from a UK center
by: Giulia Simini, et al.
Published: (2025-07-01)