Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases
Macular hole (MH) surgery generally has a high success rate, but finding anatomical plug for refractory cases remains challenging. The human amniotic membrane (hAM), with its anti-inflammatory and regenerative properties, has emerged as a potential option. This study aims to report the anatomical an...
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2025-05-01
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| author | Soefiandi Soedarman Sandi Muslim Waldensius Girsang Elvioza Referano Agustiawan Alberthus Donni Budi Prasetya Ichsan Fauzi Triyoga |
| author_facet | Soefiandi Soedarman Sandi Muslim Waldensius Girsang Elvioza Referano Agustiawan Alberthus Donni Budi Prasetya Ichsan Fauzi Triyoga |
| author_sort | Soefiandi Soedarman |
| collection | DOAJ |
| description | Macular hole (MH) surgery generally has a high success rate, but finding anatomical plug for refractory cases remains challenging. The human amniotic membrane (hAM), with its anti-inflammatory and regenerative properties, has emerged as a potential option. This study aims to report the anatomical and functional outcomes of human amniotic membrane (hAM) graft as an intervention to repair refractory macular hole cases where wide internal limiting membrane (ILM) peeling was unsuccessful. A retrospective chart review was conducted at a single center, with the main outcomes being closure rate and postoperative BCVA at 6 months. Eleven eyes of 11 patients with refractory macular holes were identified and included in the study. Participants were predominantly males (72.73%) with a mean age of 49.27 years. Nine eyes achieved successful MH closure with a single intervention and showed no recurrence during the 6-month follow-up. Mean BCVA at 3 and 6 months improved significantly (<i>p</i> = 0.0207) from 1.747 ± 0.74 logMAR to 1.210 ± 0.51 logMAR and 0.939 ± 0.47 logMAR (range 2.079–0.301 logMAR). The use of human amniotic membrane (hAM) graft seems to be a viable and effective alternative for the treatment of refractory macular holes. However, further larger prospective controlled studies are necessary to confirm our results. |
| format | Article |
| id | doaj-art-df7285aa7a51479ebf982a07856a3202 |
| institution | Kabale University |
| issn | 2411-5150 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Vision |
| spelling | doaj-art-df7285aa7a51479ebf982a07856a32022025-08-20T03:32:31ZengMDPI AGVision2411-51502025-05-01924510.3390/vision9020045Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole CasesSoefiandi Soedarman0Sandi Muslim1Waldensius Girsang2Elvioza3Referano Agustiawan4Alberthus Donni Budi Prasetya5Ichsan Fauzi Triyoga6JEC Eye Hospitals & Clinics, Jakarta 10310, IndonesiaJEC Eye Hospitals & Clinics Candi @Semarang, Semarang 50149, IndonesiaJEC Eye Hospitals & Clinics, Jakarta 10310, IndonesiaJEC Eye Hospitals & Clinics, Jakarta 10310, IndonesiaJEC Eye Hospitals & Clinics, Jakarta 10310, IndonesiaJEC Eye Hospital & Clinics Primasana @Tanjung Priok, Jakarta 14320, IndonesiaFaculty of Medicine, University of Indonesia, Jakarta 10430, IndonesiaMacular hole (MH) surgery generally has a high success rate, but finding anatomical plug for refractory cases remains challenging. The human amniotic membrane (hAM), with its anti-inflammatory and regenerative properties, has emerged as a potential option. This study aims to report the anatomical and functional outcomes of human amniotic membrane (hAM) graft as an intervention to repair refractory macular hole cases where wide internal limiting membrane (ILM) peeling was unsuccessful. A retrospective chart review was conducted at a single center, with the main outcomes being closure rate and postoperative BCVA at 6 months. Eleven eyes of 11 patients with refractory macular holes were identified and included in the study. Participants were predominantly males (72.73%) with a mean age of 49.27 years. Nine eyes achieved successful MH closure with a single intervention and showed no recurrence during the 6-month follow-up. Mean BCVA at 3 and 6 months improved significantly (<i>p</i> = 0.0207) from 1.747 ± 0.74 logMAR to 1.210 ± 0.51 logMAR and 0.939 ± 0.47 logMAR (range 2.079–0.301 logMAR). The use of human amniotic membrane (hAM) graft seems to be a viable and effective alternative for the treatment of refractory macular holes. However, further larger prospective controlled studies are necessary to confirm our results.https://www.mdpi.com/2411-5150/9/2/45refractory macular holehuman amniotic membrane (hAM) graftamniotic membrane transplantation (AMT)macular surgery |
| spellingShingle | Soefiandi Soedarman Sandi Muslim Waldensius Girsang Elvioza Referano Agustiawan Alberthus Donni Budi Prasetya Ichsan Fauzi Triyoga Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases Vision refractory macular hole human amniotic membrane (hAM) graft amniotic membrane transplantation (AMT) macular surgery |
| title | Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases |
| title_full | Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases |
| title_fullStr | Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases |
| title_full_unstemmed | Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases |
| title_short | Anatomical and Functional Outcomes of Human-Amniotic Membrane Graft in Refractory Macular Hole Cases |
| title_sort | anatomical and functional outcomes of human amniotic membrane graft in refractory macular hole cases |
| topic | refractory macular hole human amniotic membrane (hAM) graft amniotic membrane transplantation (AMT) macular surgery |
| url | https://www.mdpi.com/2411-5150/9/2/45 |
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