Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

Persistently low white blood cell count (WBC) and neutrophil count is a well-described phenomenon in persons of African ancestry, whose etiology remains unknown. We recently used admixture mapping to identify an approximately 1-megabase region on chromosome 1, where ancestry status (African or Europ...

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Main Authors: David Reich, Michael A Nalls, W H Linda Kao, Ermeg L Akylbekova, Arti Tandon, Nick Patterson, James Mullikin, Wen-Chi Hsueh, Ching-Yu Cheng, Josef Coresh, Eric Boerwinkle, Man Li, Alicja Waliszewska, Julie Neubauer, Rongling Li, Tennille S Leak, Lynette Ekunwe, Joe C Files, Cheryl L Hardy, Joseph M Zmuda, Herman A Taylor, Elad Ziv, Tamara B Harris, James G Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000360&type=printable
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