Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes?
Objective: The aim of this study was to analyze the impact of treatment complications on outcomes in adult spinal deformity (ASD) using a decision analysis (DA) model. Methods: The study included 535 ASD patients (371 with non-surgical (NS) and 164 with surgical (S) treatment) from an international...
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| Format: | Article |
| Language: | English |
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2017-05-01
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| Series: | Acta Orthopaedica et Traumatologica Turcica |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1017995X16300414 |
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| author | Emre Acaroglu Umit Ozgur Guler Aysun Cetinyurek-Yavuz Selcen Yuksel Yasemin Yavuz Selim Ayhan Montse Domingo-Sabat Ferran Pellise Ahmet Alanay Francesco S. Perez Grueso Frank Kleinstück Ibrahim Obeid |
| author_facet | Emre Acaroglu Umit Ozgur Guler Aysun Cetinyurek-Yavuz Selcen Yuksel Yasemin Yavuz Selim Ayhan Montse Domingo-Sabat Ferran Pellise Ahmet Alanay Francesco S. Perez Grueso Frank Kleinstück Ibrahim Obeid |
| author_sort | Emre Acaroglu |
| collection | DOAJ |
| description | Objective: The aim of this study was to analyze the impact of treatment complications on outcomes in adult spinal deformity (ASD) using a decision analysis (DA) model. Methods: The study included 535 ASD patients (371 with non-surgical (NS) and 164 with surgical (S) treatment) from an international multicentre database of ASD patients. DA was structured in two main steps; 1) Baseline analysis (Assessing the probabilities of outcomes, Assessing the values of preference -utilities-, Combining information on probability and utility and assigning the quality adjusted life expectancy (QALE) for each treatment) and 2) Sensitivity analysis. Complications were analyzed as life threatening (LT) and nonlife threatening (NLT) and their probabilities were calculated from the database as well as a thorough literature review. Outcomes were analyzed as improvement, no change and deterioration. Death/complete paralysis was considered as a separate category. Results: All 535 patients were analyzed in regard to complications. Overall, there were 78 NLT and 12 LT complications and 3 death/paralysis. Surgical treatment offered significantly higher chances of clinical improvement but also was significantly more prone to complications (31.7% vs. 11.1%, p < 0.001). Conclusion: Surgical treatment of ASD is more likely to cause complications compared to NS treatment. On the other hand, surgery has been shown to provide a higher likelihood of improvement in HRQoL scores. So, the decision on the type of treatment in ASD needs to take both chances of improvement and burden associated with S or NS treatments and better be arrived by the active participation of patients and physicians equipped with the present information. Level of evidence: Level II, Decision analysis. Keywords: Adult spinal deformity, Decision analysis, Treatment, Surgery, Complications |
| format | Article |
| id | doaj-art-df7048cff88d49e49b227b893f256ac6 |
| institution | Kabale University |
| issn | 1017-995X |
| language | English |
| publishDate | 2017-05-01 |
| publisher | AVES |
| record_format | Article |
| series | Acta Orthopaedica et Traumatologica Turcica |
| spelling | doaj-art-df7048cff88d49e49b227b893f256ac62025-08-20T03:58:03ZengAVESActa Orthopaedica et Traumatologica Turcica1017-995X2017-05-0151318119010.1016/j.aott.2017.03.003Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes?Emre Acaroglu0Umit Ozgur Guler1Aysun Cetinyurek-Yavuz2Selcen Yuksel3Yasemin Yavuz4Selim Ayhan5Montse Domingo-Sabat6Ferran Pellise7Ahmet Alanay8Francesco S. Perez Grueso9Frank Kleinstück10Ibrahim Obeid11Ankara Spine Center, Ankara, Turkey; Corresponding author. Ankara Spine Center, Iran Caddesi 45/2 Kavaklidere, Ankara, 06700, Turkey. Fax: +90 312 4673915.Ankara Spine Center, Ankara, TurkeyClinistats EU, Zurich, SwitzerlandYildirim Beyazit University, Ankara, TurkeyAnkara University, Ankara, TurkeyAnkara Spine Center, Ankara, TurkeyHospital Universitari Valld'Hebron, Barcelona, SpainHospital Universitari Valld'Hebron, Barcelona, SpainAcibadem Maslak Hospital, Istanbul, TurkeyHospital Universitari La Paz, Madrid, SpainSchultess Clinic, Zurich, SwitzerlandBordeaux University Hospital, Bordeaux, FranceObjective: The aim of this study was to analyze the impact of treatment complications on outcomes in adult spinal deformity (ASD) using a decision analysis (DA) model. Methods: The study included 535 ASD patients (371 with non-surgical (NS) and 164 with surgical (S) treatment) from an international multicentre database of ASD patients. DA was structured in two main steps; 1) Baseline analysis (Assessing the probabilities of outcomes, Assessing the values of preference -utilities-, Combining information on probability and utility and assigning the quality adjusted life expectancy (QALE) for each treatment) and 2) Sensitivity analysis. Complications were analyzed as life threatening (LT) and nonlife threatening (NLT) and their probabilities were calculated from the database as well as a thorough literature review. Outcomes were analyzed as improvement, no change and deterioration. Death/complete paralysis was considered as a separate category. Results: All 535 patients were analyzed in regard to complications. Overall, there were 78 NLT and 12 LT complications and 3 death/paralysis. Surgical treatment offered significantly higher chances of clinical improvement but also was significantly more prone to complications (31.7% vs. 11.1%, p < 0.001). Conclusion: Surgical treatment of ASD is more likely to cause complications compared to NS treatment. On the other hand, surgery has been shown to provide a higher likelihood of improvement in HRQoL scores. So, the decision on the type of treatment in ASD needs to take both chances of improvement and burden associated with S or NS treatments and better be arrived by the active participation of patients and physicians equipped with the present information. Level of evidence: Level II, Decision analysis. Keywords: Adult spinal deformity, Decision analysis, Treatment, Surgery, Complicationshttp://www.sciencedirect.com/science/article/pii/S1017995X16300414 |
| spellingShingle | Emre Acaroglu Umit Ozgur Guler Aysun Cetinyurek-Yavuz Selcen Yuksel Yasemin Yavuz Selim Ayhan Montse Domingo-Sabat Ferran Pellise Ahmet Alanay Francesco S. Perez Grueso Frank Kleinstück Ibrahim Obeid Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes? Acta Orthopaedica et Traumatologica Turcica |
| title | Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes? |
| title_full | Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes? |
| title_fullStr | Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes? |
| title_full_unstemmed | Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes? |
| title_short | Decision analysis to identify the ideal treatment for adult spinal deformity: What is the impact of complications on treatment outcomes? |
| title_sort | decision analysis to identify the ideal treatment for adult spinal deformity what is the impact of complications on treatment outcomes |
| url | http://www.sciencedirect.com/science/article/pii/S1017995X16300414 |
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