The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study
Abstract Background We explored if the administration of fluoxetine, recognized for its potential in adipocyte browning, entails a differential risk of coronary heart disease (CHD) in comparison to other SSRI medications. Methods Using the National Health Insurance Research Database of Taiwan from 2...
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BMC
2024-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-024-04280-5 |
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| author | Fang-Ling Li Yu-Tse Sheih Ming-Hsun Lin Yong-Chen Chen Wen-Tung Wu Tsung-Kun Lin Yu‐Ching Chou Chien‐An Sun |
| author_facet | Fang-Ling Li Yu-Tse Sheih Ming-Hsun Lin Yong-Chen Chen Wen-Tung Wu Tsung-Kun Lin Yu‐Ching Chou Chien‐An Sun |
| author_sort | Fang-Ling Li |
| collection | DOAJ |
| description | Abstract Background We explored if the administration of fluoxetine, recognized for its potential in adipocyte browning, entails a differential risk of coronary heart disease (CHD) in comparison to other SSRI medications. Methods Using the National Health Insurance Research Database of Taiwan from 2000 to 2013, we conducted a retrospective cohort study. The exposure cohort comprised individuals prescribed fluoxetine for over 90 days (n = 2,228). Conversely, those administered other SSRIs (excluding fluoxetine) for a duration surpassing 90 days were designated as the non-exposed cohort (n = 8,912). CHD incidence served as our primary outcome measure, and we employed Cox proportional hazards models to scrutinize the relationship between fluoxetine exposure and CHD development rates. Results Compared with the non-exposed cohort, the fluoxetine use had a significantly decreased 21% risk of developing CHD in the exposed cohort (adjusted hazard ratio: 0.79%, 95% confidence interval: 0.68–0.92). Noticeably, results indicated that there was an inverse association between the fluoxetine exposure and the risk of CHD, regardless of whether men, women or other age groups. Conclusion Our findings suggest that clinical use of fluoxetine was associated with a 21% reduced risk of CHD relative to other SSRI prescriptions. |
| format | Article |
| id | doaj-art-df6a2c72a10b41319100c92fbc7e4468 |
| institution | OA Journals |
| issn | 1471-2261 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-df6a2c72a10b41319100c92fbc7e44682025-08-20T02:13:27ZengBMCBMC Cardiovascular Disorders1471-22612024-11-012411810.1186/s12872-024-04280-5The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort studyFang-Ling Li0Yu-Tse Sheih1Ming-Hsun Lin2Yong-Chen Chen3Wen-Tung Wu4Tsung-Kun Lin5Yu‐Ching Chou6Chien‐An Sun7Department of Psychiatry, Tri-Service General Hospital Beitou Branch, National Defense Medical CenterDepartment of Internal Medicine, Kaohsiung Armed Forces General HospitalDivision of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical CenterData Science Center, College of Medicine, Fu-Jen Catholic UniversityDepartment of Pharmacy, Tri-Service General Hospital, National Defense Medical CenterDepartment of Pharmacy, Tri-Service General Hospital, National Defense Medical CenterSchool of Public Health, National Defense Medical CenterData Science Center, College of Medicine, Fu-Jen Catholic UniversityAbstract Background We explored if the administration of fluoxetine, recognized for its potential in adipocyte browning, entails a differential risk of coronary heart disease (CHD) in comparison to other SSRI medications. Methods Using the National Health Insurance Research Database of Taiwan from 2000 to 2013, we conducted a retrospective cohort study. The exposure cohort comprised individuals prescribed fluoxetine for over 90 days (n = 2,228). Conversely, those administered other SSRIs (excluding fluoxetine) for a duration surpassing 90 days were designated as the non-exposed cohort (n = 8,912). CHD incidence served as our primary outcome measure, and we employed Cox proportional hazards models to scrutinize the relationship between fluoxetine exposure and CHD development rates. Results Compared with the non-exposed cohort, the fluoxetine use had a significantly decreased 21% risk of developing CHD in the exposed cohort (adjusted hazard ratio: 0.79%, 95% confidence interval: 0.68–0.92). Noticeably, results indicated that there was an inverse association between the fluoxetine exposure and the risk of CHD, regardless of whether men, women or other age groups. Conclusion Our findings suggest that clinical use of fluoxetine was associated with a 21% reduced risk of CHD relative to other SSRI prescriptions.https://doi.org/10.1186/s12872-024-04280-5Cohort studyFluoxetineSelective serotonin reuptake inhibitorCoronary heart disease |
| spellingShingle | Fang-Ling Li Yu-Tse Sheih Ming-Hsun Lin Yong-Chen Chen Wen-Tung Wu Tsung-Kun Lin Yu‐Ching Chou Chien‐An Sun The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study BMC Cardiovascular Disorders Cohort study Fluoxetine Selective serotonin reuptake inhibitor Coronary heart disease |
| title | The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study |
| title_full | The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study |
| title_fullStr | The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study |
| title_full_unstemmed | The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study |
| title_short | The association between the fluoxetine use and the occurrence of coronary heart disease: a nationwide retrospective cohort study |
| title_sort | association between the fluoxetine use and the occurrence of coronary heart disease a nationwide retrospective cohort study |
| topic | Cohort study Fluoxetine Selective serotonin reuptake inhibitor Coronary heart disease |
| url | https://doi.org/10.1186/s12872-024-04280-5 |
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