Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials
Background: Chronic fatigue is a predominant symptom of post COVID-19 condition, or long COVID. We aimed to evaluate the efficacy and safety of Traditional, Complementary and Integrative Medicine (TCIM) for fatigue post COVID-19 infection. Methods: Ten English and Chinese language databases and grey...
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Elsevier
2024-06-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422024000192 |
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| author | Xiao-ying Chen Chun-li Lu Qian-yun Wang Xing-ru Pan Yang-yang Zhang Jia-le Wang Jun-Ya Liao Nai-chong Hu Chen-yang Wang Bing-jie Duan Xue-han Liu Xin-yan Jin Jennifer Hunter Jian-ping Liu |
| author_facet | Xiao-ying Chen Chun-li Lu Qian-yun Wang Xing-ru Pan Yang-yang Zhang Jia-le Wang Jun-Ya Liao Nai-chong Hu Chen-yang Wang Bing-jie Duan Xue-han Liu Xin-yan Jin Jennifer Hunter Jian-ping Liu |
| author_sort | Xiao-ying Chen |
| collection | DOAJ |
| description | Background: Chronic fatigue is a predominant symptom of post COVID-19 condition, or long COVID. We aimed to evaluate the efficacy and safety of Traditional, Complementary and Integrative Medicine (TCIM) for fatigue post COVID-19 infection. Methods: Ten English and Chinese language databases and grey literature were searched up to 12 April 2023 for randomized controlled trials (RCTs). Cochrane “Risk of bias” (RoB) tool was applied. Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). Results: Thirteen RCTs with 1632 participants were included. One RCT showed that Bufei Huoxue herbal capsules reduced fatigue (n=129, MD -14.90, 95%CI -24.53 to -5.27), one RCT reported that Ludangshen herbal liquid lowered fatigue (n=184, MD -1.90, 95%CI -2.38 to -1.42), and the other one RCT shown that fatigue disappearance rate was higher with Ludangshen herbal liquid (n=184, RR 4.19, 95%CI 2.06 to 8.53). Compared to traditional Chinese medicine rehabilitation (TCM-rahab) alone, one RCT showed that fatigue symptoms were lower following Qingjin Yiqi granules plus TCM-rehab (n=388, MD -0.48, 95%CI -0.50 to -0.46). Due to concerns with RoB and/or imprecision, the certainty in this evidence was low to very low. No serious adverse events was reported. Conclusions: Limited evidence suggests that various TCIM interventions might reduce post COVID-19 fatigue. Larger, high quality RCTs of longer duration are required to confirm these preliminary findings. Study Registration: The protocol of this review has been registered at PROSPERO: CRD42022384136. |
| format | Article |
| id | doaj-art-df6864667e5f4f8e9ba3a0a1f8d0a362 |
| institution | Kabale University |
| issn | 2213-4220 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-df6864667e5f4f8e9ba3a0a1f8d0a3622025-08-20T03:25:59ZengElsevierIntegrative Medicine Research2213-42202024-06-0113210103910.1016/j.imr.2024.101039Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trialsXiao-ying Chen0Chun-li Lu1Qian-yun Wang2Xing-ru Pan3Yang-yang Zhang4Jia-le Wang5Jun-Ya Liao6Nai-chong Hu7Chen-yang Wang8Bing-jie Duan9Xue-han Liu10Xin-yan Jin11Jennifer Hunter12Jian-ping Liu13Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaGuangdong Pharmaceutical University, Guangzhou, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; The Second Clinical Medical School, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; The Second Clinical Medical School, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, China, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, China, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, China, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaHealth Research Group, Sydney, Australia; School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Corresponding author at: Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.Background: Chronic fatigue is a predominant symptom of post COVID-19 condition, or long COVID. We aimed to evaluate the efficacy and safety of Traditional, Complementary and Integrative Medicine (TCIM) for fatigue post COVID-19 infection. Methods: Ten English and Chinese language databases and grey literature were searched up to 12 April 2023 for randomized controlled trials (RCTs). Cochrane “Risk of bias” (RoB) tool was applied. Evidence certainty was assessed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE). Effect estimates were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). Results: Thirteen RCTs with 1632 participants were included. One RCT showed that Bufei Huoxue herbal capsules reduced fatigue (n=129, MD -14.90, 95%CI -24.53 to -5.27), one RCT reported that Ludangshen herbal liquid lowered fatigue (n=184, MD -1.90, 95%CI -2.38 to -1.42), and the other one RCT shown that fatigue disappearance rate was higher with Ludangshen herbal liquid (n=184, RR 4.19, 95%CI 2.06 to 8.53). Compared to traditional Chinese medicine rehabilitation (TCM-rahab) alone, one RCT showed that fatigue symptoms were lower following Qingjin Yiqi granules plus TCM-rehab (n=388, MD -0.48, 95%CI -0.50 to -0.46). Due to concerns with RoB and/or imprecision, the certainty in this evidence was low to very low. No serious adverse events was reported. Conclusions: Limited evidence suggests that various TCIM interventions might reduce post COVID-19 fatigue. Larger, high quality RCTs of longer duration are required to confirm these preliminary findings. Study Registration: The protocol of this review has been registered at PROSPERO: CRD42022384136.http://www.sciencedirect.com/science/article/pii/S2213422024000192Post COVID conditionChronic fatigueTraditional medicineComplementary medicineIntegrative medicine |
| spellingShingle | Xiao-ying Chen Chun-li Lu Qian-yun Wang Xing-ru Pan Yang-yang Zhang Jia-le Wang Jun-Ya Liao Nai-chong Hu Chen-yang Wang Bing-jie Duan Xue-han Liu Xin-yan Jin Jennifer Hunter Jian-ping Liu Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials Integrative Medicine Research Post COVID condition Chronic fatigue Traditional medicine Complementary medicine Integrative medicine |
| title | Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials |
| title_full | Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials |
| title_fullStr | Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials |
| title_full_unstemmed | Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials |
| title_short | Traditional, complementary and integrative medicine for fatigue post COVID-19 infection: A systematic review of randomized controlled trials |
| title_sort | traditional complementary and integrative medicine for fatigue post covid 19 infection a systematic review of randomized controlled trials |
| topic | Post COVID condition Chronic fatigue Traditional medicine Complementary medicine Integrative medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2213422024000192 |
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