Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics
Aim. Formation of the basic structures for virtual libraries is an important step during the docking studies, which are currently used in the search of new substances. For the purpose of the logical framework approach use in the planning stages of research we have analyzed the current assortment and...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2015-04-01
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| Series: | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
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| Online Access: | http://pharmed.zsmu.edu.ua/article/view/41340/37750 |
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| _version_ | 1850058711711612928 |
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| author | A. І. Abu Shark P. O. Bezugly G. O. Burian |
| author_facet | A. І. Abu Shark P. O. Bezugly G. O. Burian |
| author_sort | A. І. Abu Shark |
| collection | DOAJ |
| description | Aim. Formation of the basic structures for virtual libraries is an important step during the docking studies, which are currently used in the search of new substances. For the purpose of the logical framework approach use in the planning stages of research we have analyzed the current assortment and mechanisms of action for drugs with spasmolytic action according to their chemical structure.
Results. It has been established that the most probable mechanism of action for amidated derivatives of 2-hydroxy-4-oxo-4H-pyrido [1,2a]pyrimidine-3-carboxylic acid, which are substituted in the pyridine ring, in the presence of similar structural fragments is the base inhibition of PDE. |
| format | Article |
| id | doaj-art-df66222ed49147f4b1c43951d7c3d086 |
| institution | DOAJ |
| issn | 2306-8094 2409-2932 |
| language | English |
| publishDate | 2015-04-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki |
| spelling | doaj-art-df66222ed49147f4b1c43951d7c3d0862025-08-20T02:51:04ZengZaporizhzhia State Medical and Pharmaceutical UniversityAktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki2306-80942409-29322015-04-011121610.14739/2409-2932.2015.1.41340Theoretical justification of basic structures for purposeful synthesis of potential antispasmodicsA. І. Abu SharkP. O. BezuglyG. O. BurianAim. Formation of the basic structures for virtual libraries is an important step during the docking studies, which are currently used in the search of new substances. For the purpose of the logical framework approach use in the planning stages of research we have analyzed the current assortment and mechanisms of action for drugs with spasmolytic action according to their chemical structure. Results. It has been established that the most probable mechanism of action for amidated derivatives of 2-hydroxy-4-oxo-4H-pyrido [1,2a]pyrimidine-3-carboxylic acid, which are substituted in the pyridine ring, in the presence of similar structural fragments is the base inhibition of PDE.http://pharmed.zsmu.edu.ua/article/view/41340/37750ParasympatholyticsChemical SynthesisResearchChemical structure |
| spellingShingle | A. І. Abu Shark P. O. Bezugly G. O. Burian Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki Parasympatholytics Chemical Synthesis Research Chemical structure |
| title | Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics |
| title_full | Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics |
| title_fullStr | Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics |
| title_full_unstemmed | Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics |
| title_short | Theoretical justification of basic structures for purposeful synthesis of potential antispasmodics |
| title_sort | theoretical justification of basic structures for purposeful synthesis of potential antispasmodics |
| topic | Parasympatholytics Chemical Synthesis Research Chemical structure |
| url | http://pharmed.zsmu.edu.ua/article/view/41340/37750 |
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