Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection
Introduction: Diabetic foot infection (DFI) can result in lower extremity amputation and death in patients with diabetes and is an important cause of morbidity and mortality. The purpose of this study was to identify predictive factors for adverse outcomes consisting of major lower extremity amputa...
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The Journal of Infection in Developing Countries
2025-04-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/19974 |
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| author | Rukiye İnan Sarikaya Ömer Karaşahin |
| author_facet | Rukiye İnan Sarikaya Ömer Karaşahin |
| author_sort | Rukiye İnan Sarikaya |
| collection | DOAJ |
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Introduction: Diabetic foot infection (DFI) can result in lower extremity amputation and death in patients with diabetes and is an important cause of morbidity and mortality. The purpose of this study was to identify predictive factors for adverse outcomes consisting of major lower extremity amputation and mortality in patients with DFI.
Methodology: One hundred and two patients diagnosed with DFI and followed up in a tertiary hospital between November 2022 and April 2023 were included in this prospective study. Demographic and diabetic foot characteristics at the time of presentation, degrees of DFI, and clinical and laboratory findings of all patients were recorded. Major amputation and/or mortality were regarded as adverse outcomes. The patients were followed up throughout hospitalization until discharge or mortality. Risk factors for adverse outcomes were identified using univariate and multivariate logistic regression analyses.
Results: The median age of the patients was 60.0 years, and the majority (72.5%) were men. Adverse outcomes developed in 11 patients during follow-up. The factors linked to adverse outcomes included fever; wound necrosis; isolation of Enterobacteriaceae species in wound culture; perfusion, extent, depth, infection, and sensation (PEDIS) grade 4; and blood urea nitrogen (BUN) elevation. Following multivariate logistic regression analysis, only BUN > 31 mg/dL and presence of necrosis emerged as significant independent predictive factors for adverse outcomes.
Conclusions: The findings show that the above factors may be useful in predicting adverse outcomes in patients with DFI. Early detection of these factors may be useful in preventing morbidity and mortality in these patients.
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| format | Article |
| id | doaj-art-df63b80cde244ed7aa0e77841de60154 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-df63b80cde244ed7aa0e77841de601542025-08-20T02:57:03ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802025-04-01190410.3855/jidc.19974Risk factors affecting the development of adverse outcomes in patients with diabetic foot infectionRukiye İnan Sarikaya0Ömer Karaşahin1Department of Infectious Diseases and Clinical Microbiology, Health Sciences University, Erzurum Regional Training and Research Hospital, Erzurum, TurkeyDepartment of Infectious Diseases and Clinical Microbiology, Health Sciences University, Erzurum Regional Training and Research Hospital, Erzurum, Turkey Introduction: Diabetic foot infection (DFI) can result in lower extremity amputation and death in patients with diabetes and is an important cause of morbidity and mortality. The purpose of this study was to identify predictive factors for adverse outcomes consisting of major lower extremity amputation and mortality in patients with DFI. Methodology: One hundred and two patients diagnosed with DFI and followed up in a tertiary hospital between November 2022 and April 2023 were included in this prospective study. Demographic and diabetic foot characteristics at the time of presentation, degrees of DFI, and clinical and laboratory findings of all patients were recorded. Major amputation and/or mortality were regarded as adverse outcomes. The patients were followed up throughout hospitalization until discharge or mortality. Risk factors for adverse outcomes were identified using univariate and multivariate logistic regression analyses. Results: The median age of the patients was 60.0 years, and the majority (72.5%) were men. Adverse outcomes developed in 11 patients during follow-up. The factors linked to adverse outcomes included fever; wound necrosis; isolation of Enterobacteriaceae species in wound culture; perfusion, extent, depth, infection, and sensation (PEDIS) grade 4; and blood urea nitrogen (BUN) elevation. Following multivariate logistic regression analysis, only BUN > 31 mg/dL and presence of necrosis emerged as significant independent predictive factors for adverse outcomes. Conclusions: The findings show that the above factors may be useful in predicting adverse outcomes in patients with DFI. Early detection of these factors may be useful in preventing morbidity and mortality in these patients. https://jidc.org/index.php/journal/article/view/19974adverse outcomeamputationdiabetic footinfectionmortality |
| spellingShingle | Rukiye İnan Sarikaya Ömer Karaşahin Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection Journal of Infection in Developing Countries adverse outcome amputation diabetic foot infection mortality |
| title | Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection |
| title_full | Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection |
| title_fullStr | Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection |
| title_full_unstemmed | Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection |
| title_short | Risk factors affecting the development of adverse outcomes in patients with diabetic foot infection |
| title_sort | risk factors affecting the development of adverse outcomes in patients with diabetic foot infection |
| topic | adverse outcome amputation diabetic foot infection mortality |
| url | https://jidc.org/index.php/journal/article/view/19974 |
| work_keys_str_mv | AT rukiyeinansarikaya riskfactorsaffectingthedevelopmentofadverseoutcomesinpatientswithdiabeticfootinfection AT omerkarasahin riskfactorsaffectingthedevelopmentofadverseoutcomesinpatientswithdiabeticfootinfection |