The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages
The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, lept...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/6790794 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556097339129856 |
|---|---|
| author | Hui juan Zhu Su juan Li Hui Pan Naishi Li Dian xi Zhang Lin jie Wang Hong bo Yang Qinyong Wu Feng ying Gong |
| author_facet | Hui juan Zhu Su juan Li Hui Pan Naishi Li Dian xi Zhang Lin jie Wang Hong bo Yang Qinyong Wu Feng ying Gong |
| author_sort | Hui juan Zhu |
| collection | DOAJ |
| description | The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P<0.05). Conversely, serum kisspeptin levels of boys were higher in T4 and T5 stages than those in T1 stage, while its levels of girls were the highest in T2 stage, 21.4% higher than those in T1 stage (P<0.05). Both leptin and kisspeptin levels were positively correlated with BMI, WC, and weight in all boys and girls (all P<0.05). In conclusion, kisspeptin levels were firstly found to be notably changed in pubertal stages and nutritional status in Chinese children and adolescents with a significant sexual dimorphism. Obese/overweight girls had higher kisspeptin levels, and there was a positive correlation between kisspeptin and FSH and LH and obesity-related parameters in all boys and girls. |
| format | Article |
| id | doaj-art-df63b0d6a4af4294acee535813d69704 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-df63b0d6a4af4294acee535813d697042025-02-03T05:46:22ZengWileyInternational Journal of Endocrinology1687-83371687-83452016-01-01201610.1155/2016/67907946790794The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal StagesHui juan Zhu0Su juan Li1Hui Pan2Naishi Li3Dian xi Zhang4Lin jie Wang5Hong bo Yang6Qinyong Wu7Feng ying Gong8Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, ChinaThe aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P<0.05). Conversely, serum kisspeptin levels of boys were higher in T4 and T5 stages than those in T1 stage, while its levels of girls were the highest in T2 stage, 21.4% higher than those in T1 stage (P<0.05). Both leptin and kisspeptin levels were positively correlated with BMI, WC, and weight in all boys and girls (all P<0.05). In conclusion, kisspeptin levels were firstly found to be notably changed in pubertal stages and nutritional status in Chinese children and adolescents with a significant sexual dimorphism. Obese/overweight girls had higher kisspeptin levels, and there was a positive correlation between kisspeptin and FSH and LH and obesity-related parameters in all boys and girls.http://dx.doi.org/10.1155/2016/6790794 |
| spellingShingle | Hui juan Zhu Su juan Li Hui Pan Naishi Li Dian xi Zhang Lin jie Wang Hong bo Yang Qinyong Wu Feng ying Gong The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages International Journal of Endocrinology |
| title | The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages |
| title_full | The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages |
| title_fullStr | The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages |
| title_full_unstemmed | The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages |
| title_short | The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages |
| title_sort | changes of serum leptin and kisspeptin levels in chinese children and adolescents in different pubertal stages |
| url | http://dx.doi.org/10.1155/2016/6790794 |
| work_keys_str_mv | AT huijuanzhu thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT sujuanli thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT huipan thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT naishili thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT dianxizhang thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT linjiewang thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT hongboyang thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT qinyongwu thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT fengyinggong thechangesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT huijuanzhu changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT sujuanli changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT huipan changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT naishili changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT dianxizhang changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT linjiewang changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT hongboyang changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT qinyongwu changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages AT fengyinggong changesofserumleptinandkisspeptinlevelsinchinesechildrenandadolescentsindifferentpubertalstages |