Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization

Conclusion: This study establishes the causal effect of IBD on AS, PsA, and ReA. The absence of significant mediation effects suggests that IBD-associated gut dysbiosis, systemic inflammation, and calcium metabolic disturbances may not directly drive arthritis pathogenesis, challenging their utility...

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Main Authors: Sinan Xiao, Kairong Su, Hongliang Gao, Chenyang Qiao, Sumei Sha, Xin Liu, Haitao Shi
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/mi/1675577
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author Sinan Xiao
Kairong Su
Hongliang Gao
Chenyang Qiao
Sumei Sha
Xin Liu
Haitao Shi
author_facet Sinan Xiao
Kairong Su
Hongliang Gao
Chenyang Qiao
Sumei Sha
Xin Liu
Haitao Shi
author_sort Sinan Xiao
collection DOAJ
description Conclusion: This study establishes the causal effect of IBD on AS, PsA, and ReA. The absence of significant mediation effects suggests that IBD-associated gut dysbiosis, systemic inflammation, and calcium metabolic disturbances may not directly drive arthritis pathogenesis, challenging their utility as predictive biomarkers for arthritis development in IBD patients.
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institution Kabale University
issn 1466-1861
language English
publishDate 2025-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-df5fd56ae1e54fd68b50348ed32faf872025-08-20T03:45:07ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/1675577Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian RandomizationSinan Xiao0Kairong Su1Hongliang Gao2Chenyang Qiao3Sumei Sha4Xin Liu5Haitao Shi6Department of GastroenterologyDepartment of GastroenterologyThe Second Department of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyConclusion: This study establishes the causal effect of IBD on AS, PsA, and ReA. The absence of significant mediation effects suggests that IBD-associated gut dysbiosis, systemic inflammation, and calcium metabolic disturbances may not directly drive arthritis pathogenesis, challenging their utility as predictive biomarkers for arthritis development in IBD patients.http://dx.doi.org/10.1155/mi/1675577
spellingShingle Sinan Xiao
Kairong Su
Hongliang Gao
Chenyang Qiao
Sumei Sha
Xin Liu
Haitao Shi
Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization
Mediators of Inflammation
title Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization
title_full Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization
title_fullStr Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization
title_full_unstemmed Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization
title_short Association of Inflammatory Factors and Calcium Metabolism With Arthritis in Patients With Inflammatory Bowel Disease: Evidence From Mediated Mendelian Randomization
title_sort association of inflammatory factors and calcium metabolism with arthritis in patients with inflammatory bowel disease evidence from mediated mendelian randomization
url http://dx.doi.org/10.1155/mi/1675577
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