Use of Octreotide in the Acute Management of Bleeding Esophageal Varices
Acute hemorrhage from esophageal varices is a medical emergency; despite early diagnosis and treatment the associated hospital mortality remains high. The clinical research summarized in t...
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1997/156920 |
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| _version_ | 1849435145961996288 |
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| author | Daniel C Sadowski |
| author_facet | Daniel C Sadowski |
| author_sort | Daniel C Sadowski |
| collection | DOAJ |
| description | Acute hemorrhage from esophageal varices is a medical emergency; despite early diagnosis and treatment the associated hospital mortality remains high. The clinical research summarized in this paper shows that octreotide has a beneficial effect on portal hemodynamics in cirrhotic patients. In randomized controlled trials octreotide has been effective in halting initial hemorrhage and in preventing reoccurrence of bleeding. Somatostatin and octreotide appear to be equivalent in terms of therapeutic efficacy but octreotide is the less expensive option. For suspected variceal bleeding an octreotide infusion should be initiated immediately. To prevent further bleeding the drug should be continued for two to five days after endoscopic variceal ligation. |
| format | Article |
| id | doaj-art-df5b36e09d4c40bb8c70f1f4b5c15d71 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-df5b36e09d4c40bb8c70f1f4b5c15d712025-08-20T03:26:25ZengWileyCanadian Journal of Gastroenterology0835-79001997-01-0111433934310.1155/1997/156920Use of Octreotide in the Acute Management of Bleeding Esophageal VaricesDaniel C SadowskiAcute hemorrhage from esophageal varices is a medical emergency; despite early diagnosis and treatment the associated hospital mortality remains high. The clinical research summarized in this paper shows that octreotide has a beneficial effect on portal hemodynamics in cirrhotic patients. In randomized controlled trials octreotide has been effective in halting initial hemorrhage and in preventing reoccurrence of bleeding. Somatostatin and octreotide appear to be equivalent in terms of therapeutic efficacy but octreotide is the less expensive option. For suspected variceal bleeding an octreotide infusion should be initiated immediately. To prevent further bleeding the drug should be continued for two to five days after endoscopic variceal ligation.http://dx.doi.org/10.1155/1997/156920 |
| spellingShingle | Daniel C Sadowski Use of Octreotide in the Acute Management of Bleeding Esophageal Varices Canadian Journal of Gastroenterology |
| title | Use of Octreotide in the Acute Management of Bleeding Esophageal Varices |
| title_full | Use of Octreotide in the Acute Management of Bleeding Esophageal Varices |
| title_fullStr | Use of Octreotide in the Acute Management of Bleeding Esophageal Varices |
| title_full_unstemmed | Use of Octreotide in the Acute Management of Bleeding Esophageal Varices |
| title_short | Use of Octreotide in the Acute Management of Bleeding Esophageal Varices |
| title_sort | use of octreotide in the acute management of bleeding esophageal varices |
| url | http://dx.doi.org/10.1155/1997/156920 |
| work_keys_str_mv | AT danielcsadowski useofoctreotideintheacutemanagementofbleedingesophagealvarices |