The Anti-Inflammatory Roles of Vitamin D for Improving Human Health
Vitamin D receptors (VDRs) are present in almost all cells of the immune system, including B cells, T cells, NK (Natural Killer) cells, dendritic cells, and monocytes, as well as the epithelial cells of many organs such as the intestine, pancreas, prostate, lungs, and cardiomyocytes. In addition, so...
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MDPI AG
2024-11-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/46/12/807 |
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| author | Aysen Kutan Fenercioglu |
| author_facet | Aysen Kutan Fenercioglu |
| author_sort | Aysen Kutan Fenercioglu |
| collection | DOAJ |
| description | Vitamin D receptors (VDRs) are present in almost all cells of the immune system, including B cells, T cells, NK (Natural Killer) cells, dendritic cells, and monocytes, as well as the epithelial cells of many organs such as the intestine, pancreas, prostate, lungs, and cardiomyocytes. In addition, some immune cells, including dendritic cells, macrophages, and B and T cells, can synthesize calcitriol by expressing 1α-hydroxylase. Upon binding to VDRs, vitamin D (Vit D) regulates the expression of genes involved in immune responses, including those encoding for cytokines. It modulates the production of pro-inflammatory cytokines while promoting the synthesis of anti-inflammatory cytokines. Vit D also affects the differentiation and maturation of cells of the immune system. By inhibiting the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, Vit D reduces the expression of pro-inflammatory genes. These effects highlight the potential of Vit D as a therapeutic agent in the management of inflammatory diseases, including autoimmune disorders, cardiovascular diseases, diabetes, metabolic syndrome, cancer, neurological diseases, depression, and inflammatory bowel disease. |
| format | Article |
| id | doaj-art-df5952a5b57f42ba895706d331cfd47f |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Current Issues in Molecular Biology |
| spelling | doaj-art-df5952a5b57f42ba895706d331cfd47f2025-08-20T02:53:19ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-11-014612135141352510.3390/cimb46120807The Anti-Inflammatory Roles of Vitamin D for Improving Human HealthAysen Kutan Fenercioglu0Department of Family Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul 34098, TurkeyVitamin D receptors (VDRs) are present in almost all cells of the immune system, including B cells, T cells, NK (Natural Killer) cells, dendritic cells, and monocytes, as well as the epithelial cells of many organs such as the intestine, pancreas, prostate, lungs, and cardiomyocytes. In addition, some immune cells, including dendritic cells, macrophages, and B and T cells, can synthesize calcitriol by expressing 1α-hydroxylase. Upon binding to VDRs, vitamin D (Vit D) regulates the expression of genes involved in immune responses, including those encoding for cytokines. It modulates the production of pro-inflammatory cytokines while promoting the synthesis of anti-inflammatory cytokines. Vit D also affects the differentiation and maturation of cells of the immune system. By inhibiting the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) pathways, Vit D reduces the expression of pro-inflammatory genes. These effects highlight the potential of Vit D as a therapeutic agent in the management of inflammatory diseases, including autoimmune disorders, cardiovascular diseases, diabetes, metabolic syndrome, cancer, neurological diseases, depression, and inflammatory bowel disease.https://www.mdpi.com/1467-3045/46/12/807vitamin Dinflammationautoimmune diseaseimmune activation |
| spellingShingle | Aysen Kutan Fenercioglu The Anti-Inflammatory Roles of Vitamin D for Improving Human Health Current Issues in Molecular Biology vitamin D inflammation autoimmune disease immune activation |
| title | The Anti-Inflammatory Roles of Vitamin D for Improving Human Health |
| title_full | The Anti-Inflammatory Roles of Vitamin D for Improving Human Health |
| title_fullStr | The Anti-Inflammatory Roles of Vitamin D for Improving Human Health |
| title_full_unstemmed | The Anti-Inflammatory Roles of Vitamin D for Improving Human Health |
| title_short | The Anti-Inflammatory Roles of Vitamin D for Improving Human Health |
| title_sort | anti inflammatory roles of vitamin d for improving human health |
| topic | vitamin D inflammation autoimmune disease immune activation |
| url | https://www.mdpi.com/1467-3045/46/12/807 |
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