Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy
Diabetic complications are a leading cause of acquired blindness, end-stage renal failure, and accelerated atherosclerosis, which are associated with the disabilities and high mortality rates seen in diabetic patients. Continuous hyperglycemia is involved in the pathogenesis of diabetic micro- and m...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2010/170393 |
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| author | Masayoshi Takeuchi Jun-ichi Takino Sho-ichi Yamagishi |
| author_facet | Masayoshi Takeuchi Jun-ichi Takino Sho-ichi Yamagishi |
| author_sort | Masayoshi Takeuchi |
| collection | DOAJ |
| description | Diabetic complications are a leading cause of acquired blindness, end-stage renal failure, and accelerated atherosclerosis, which are associated with the disabilities and high mortality rates seen in diabetic patients. Continuous hyperglycemia is involved in the pathogenesis of diabetic micro- and macrovascular complications via various metabolic pathways, and numerous hyperglycemia-induced metabolic and hemodynamic conditions exist, including increased generation of various types of advanced glycation end-products (AGEs). Recently, we demonstrated that glyceraldehyde-derived AGEs, the predominant structure of toxic AGEs (TAGE), play an important role in the pathogenesis of angiopathy in diabetic patients. Moreover, recent evidence suggests that the interaction of TAGE with the receptor for AGEs (RAGE) elicits oxidative stress generation in numerous types of cells, all of which may contribute to the pathological changes observed in diabetic complications. In this paper, we discuss the pathophysiological role of the TAGE-RAGE system in the development and progression of diabetic retinopathy. |
| format | Article |
| id | doaj-art-df5874aac8bb4ba2a7a28e261af22a19 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-df5874aac8bb4ba2a7a28e261af22a192025-08-20T03:26:25ZengWileyJournal of Ophthalmology2090-004X2090-00582010-01-01201010.1155/2010/170393170393Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic RetinopathyMasayoshi Takeuchi0Jun-ichi Takino1Sho-ichi Yamagishi2Department of Pathophysiological Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, JapanDepartment of Pathophysiological Science, Faculty of Pharmaceutical Sciences, Hokuriku University, Ho-3 Kanagawa-machi, Kanazawa 920-1181, JapanDepartment of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, 67 Asahimachi, Kurume 830-0011, JapanDiabetic complications are a leading cause of acquired blindness, end-stage renal failure, and accelerated atherosclerosis, which are associated with the disabilities and high mortality rates seen in diabetic patients. Continuous hyperglycemia is involved in the pathogenesis of diabetic micro- and macrovascular complications via various metabolic pathways, and numerous hyperglycemia-induced metabolic and hemodynamic conditions exist, including increased generation of various types of advanced glycation end-products (AGEs). Recently, we demonstrated that glyceraldehyde-derived AGEs, the predominant structure of toxic AGEs (TAGE), play an important role in the pathogenesis of angiopathy in diabetic patients. Moreover, recent evidence suggests that the interaction of TAGE with the receptor for AGEs (RAGE) elicits oxidative stress generation in numerous types of cells, all of which may contribute to the pathological changes observed in diabetic complications. In this paper, we discuss the pathophysiological role of the TAGE-RAGE system in the development and progression of diabetic retinopathy.http://dx.doi.org/10.1155/2010/170393 |
| spellingShingle | Masayoshi Takeuchi Jun-ichi Takino Sho-ichi Yamagishi Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy Journal of Ophthalmology |
| title | Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy |
| title_full | Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy |
| title_fullStr | Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy |
| title_full_unstemmed | Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy |
| title_short | Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy |
| title_sort | involvement of tage rage system in the pathogenesis of diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2010/170393 |
| work_keys_str_mv | AT masayoshitakeuchi involvementoftageragesysteminthepathogenesisofdiabeticretinopathy AT junichitakino involvementoftageragesysteminthepathogenesisofdiabeticretinopathy AT shoichiyamagishi involvementoftageragesysteminthepathogenesisofdiabeticretinopathy |