Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

Predicting which drugs might have the potential to cause drug-induced liver injury (DILI) is highly complex and the current methods, 2D cell-based models and animal tests, are not sensitive enough to prevent some costly failures in clinical trials or to avoid all patient safety concerns for DILI pos...

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Bibliographic Details
Main Authors: K. Taylor, R. Ram, L. Ewart, C. Goldring, G. Russomanno, G. P. Aithal, T. Kostrzewski, C. Bauch, J. M. Wilkinson, S. Modi, J. G. Kenna, J. Bailey
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Drug Discovery
Subjects:
DILI
liver injury
in vitro methods
animal testing
replacement
spheroids
Online Access:https://www.frontiersin.org/articles/10.3389/fddsv.2025.1536756/full
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