A rare case of thymus lipofbroadenoma
Purpose of the study: differential diagnosis of tumors arising from the mediastinum, as well as the analysis of the biological potential of the tumor, taking into account the relatively low incidence of these tumors among the population.Material and Methods. Macroscopic and microscopic examinations...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2023-05-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/2547 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850030760250048512 |
|---|---|
| author | A. V. Shilov A. M. Avdalyan A. S. Shargin A. V. Levitsky D. N. Protsenko |
| author_facet | A. V. Shilov A. M. Avdalyan A. S. Shargin A. V. Levitsky D. N. Protsenko |
| author_sort | A. V. Shilov |
| collection | DOAJ |
| description | Purpose of the study: differential diagnosis of tumors arising from the mediastinum, as well as the analysis of the biological potential of the tumor, taking into account the relatively low incidence of these tumors among the population.Material and Methods. Macroscopic and microscopic examinations of the surgical specimen were performed using routine H&E staining. Immunohistochemical staining of paraffin-embedded tissue sections was performed using a Roche Ventana BenchMark Ultra system. The results obtained were evaluated taking into account the available literature data published on this nosology.Description. We present a rare case of a benign neoplasm of the thymus, lipofibroadenoma (LFA), which was localized in the left pleural cavity and originated from the anterior mediastinum with partial compression of the lower lobe of the left lung in a 59-year-old man. The tumor was revealed during a routine medical examination. The patient underwent left-sided thoracotomy with complete excision of the tumor and anterior mediastinal lymph node dissection. Macroscopic examination reveled that the tumor was predominantly composed of adipose tissue with fibrous layers. Histological examination showed a tumor composed of mature adipocytes of various sizes, among which remnants of the thymus with Hassal’s bodies and small number of lymphocytes and calcifications were found. Areas of fibrous stroma predominated over narrow strands of anastomosing epithelial cells with clear nuclei. Epitheliocytes formed slit-like structures infiltrated with lymphocytes, resembling the structure of breast fibroadenoma. Immunohistochemical examination revealed that epithelial cells were positive for PanKeratin and CK19, lymphocytes were positive for CD3 and CD20, and thymic cells expressed TdT. In this case, the neoplasm was almost asymptomatic, in contrast to previously published observations, which described an association with erythrocyte aplasia.Conclusion. Considering the clinical, histological and immunohistochemical data, it was feasible to make a differential diagnosis of the neoplasm and determine the histological type of the tumor as lipofibroadenoma. |
| format | Article |
| id | doaj-art-df4ddda8fa2d4d4790134781dc52f5ff |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-df4ddda8fa2d4d4790134781dc52f5ff2025-08-20T02:59:08ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682023-05-0122217518010.21294/1814-4861-2023-22-2-175-1801116A rare case of thymus lipofbroadenomaA. V. Shilov0A. M. Avdalyan1A. S. Shargin2A. V. Levitsky3D. N. Protsenko4Moscow Multidisciplinary Clinical Center “Kommunarka”Moscow Multidisciplinary Clinical Center “Kommunarka”; A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of RussiaMoscow Multidisciplinary Clinical Center “Kommunarka”Moscow Multidisciplinary Clinical Center “Kommunarka”; RUDN UniversityMoscow Multidisciplinary Clinical Center “Kommunarka”; N.I. Pirogov Russian National Research Medical University of the Ministry of Health of RussiaPurpose of the study: differential diagnosis of tumors arising from the mediastinum, as well as the analysis of the biological potential of the tumor, taking into account the relatively low incidence of these tumors among the population.Material and Methods. Macroscopic and microscopic examinations of the surgical specimen were performed using routine H&E staining. Immunohistochemical staining of paraffin-embedded tissue sections was performed using a Roche Ventana BenchMark Ultra system. The results obtained were evaluated taking into account the available literature data published on this nosology.Description. We present a rare case of a benign neoplasm of the thymus, lipofibroadenoma (LFA), which was localized in the left pleural cavity and originated from the anterior mediastinum with partial compression of the lower lobe of the left lung in a 59-year-old man. The tumor was revealed during a routine medical examination. The patient underwent left-sided thoracotomy with complete excision of the tumor and anterior mediastinal lymph node dissection. Macroscopic examination reveled that the tumor was predominantly composed of adipose tissue with fibrous layers. Histological examination showed a tumor composed of mature adipocytes of various sizes, among which remnants of the thymus with Hassal’s bodies and small number of lymphocytes and calcifications were found. Areas of fibrous stroma predominated over narrow strands of anastomosing epithelial cells with clear nuclei. Epitheliocytes formed slit-like structures infiltrated with lymphocytes, resembling the structure of breast fibroadenoma. Immunohistochemical examination revealed that epithelial cells were positive for PanKeratin and CK19, lymphocytes were positive for CD3 and CD20, and thymic cells expressed TdT. In this case, the neoplasm was almost asymptomatic, in contrast to previously published observations, which described an association with erythrocyte aplasia.Conclusion. Considering the clinical, histological and immunohistochemical data, it was feasible to make a differential diagnosis of the neoplasm and determine the histological type of the tumor as lipofibroadenoma.https://www.siboncoj.ru/jour/article/view/2547pathological anatomyoncologythymuslipofibroadenoma |
| spellingShingle | A. V. Shilov A. M. Avdalyan A. S. Shargin A. V. Levitsky D. N. Protsenko A rare case of thymus lipofbroadenoma Сибирский онкологический журнал pathological anatomy oncology thymus lipofibroadenoma |
| title | A rare case of thymus lipofbroadenoma |
| title_full | A rare case of thymus lipofbroadenoma |
| title_fullStr | A rare case of thymus lipofbroadenoma |
| title_full_unstemmed | A rare case of thymus lipofbroadenoma |
| title_short | A rare case of thymus lipofbroadenoma |
| title_sort | rare case of thymus lipofbroadenoma |
| topic | pathological anatomy oncology thymus lipofibroadenoma |
| url | https://www.siboncoj.ru/jour/article/view/2547 |
| work_keys_str_mv | AT avshilov ararecaseofthymuslipofbroadenoma AT amavdalyan ararecaseofthymuslipofbroadenoma AT asshargin ararecaseofthymuslipofbroadenoma AT avlevitsky ararecaseofthymuslipofbroadenoma AT dnprotsenko ararecaseofthymuslipofbroadenoma AT avshilov rarecaseofthymuslipofbroadenoma AT amavdalyan rarecaseofthymuslipofbroadenoma AT asshargin rarecaseofthymuslipofbroadenoma AT avlevitsky rarecaseofthymuslipofbroadenoma AT dnprotsenko rarecaseofthymuslipofbroadenoma |