Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactions
Recent progress in nonlocal photonic modes within all-dielectric metasurfaces has established them as a promising alternative to traditional surface plasmon resonance technique for real-time monitoring of molecular interactions with high sensitivity. However, current implementations rely on optical...
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| Format: | Article |
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AIP Publishing LLC
2025-03-01
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| Series: | APL Photonics |
| Online Access: | http://dx.doi.org/10.1063/5.0253249 |
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| author | Yujiao Bi Yuechun Shi Zhanghua Han |
| author_facet | Yujiao Bi Yuechun Shi Zhanghua Han |
| author_sort | Yujiao Bi |
| collection | DOAJ |
| description | Recent progress in nonlocal photonic modes within all-dielectric metasurfaces has established them as a promising alternative to traditional surface plasmon resonance technique for real-time monitoring of molecular interactions with high sensitivity. However, current implementations rely on optical spectroscopy to detect spectral changes, leading to expensive instrumentation. Here, we introduce an innovative approach that leverages the high-Q quasi-guided modes (QGMs) within all-dielectric nonlocal metasurfaces, utilizing angular interrogation as the detection mechanism. The pronounced spatial dispersion profile of the QGM allows for the detection of refractive index variations through the resonant angle of incidence. This method simplifies the detection process, using a simple continuous wave laser, thus eliminating the need for costly optical spectroscopy setups. Our experimental validation, conducted using a dimerized-hole photonic crystal slab, demonstrates effective characterization of the streptavidin–biotin binding interaction with remarkable sensitivity, detecting streptavidin with a threshold of less than 0.1 nM. This showcases the potential of our approach in molecular sensing applications. |
| format | Article |
| id | doaj-art-df4d5083da6946309a2d232feb0748d0 |
| institution | DOAJ |
| issn | 2378-0967 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | APL Photonics |
| spelling | doaj-art-df4d5083da6946309a2d232feb0748d02025-08-20T03:06:18ZengAIP Publishing LLCAPL Photonics2378-09672025-03-01103036124036124-710.1063/5.0253249Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactionsYujiao Bi0Yuechun Shi1Zhanghua Han2Shandong Provincial Key Laboratory of Optics and Photonic Devices, Center of Light Manipulation and Applications, School of Physics and Electronics, Shandong Normal University, Jinan 250358, ChinaYongjiang Laboratory, Ningbo 315202, ChinaShandong Provincial Key Laboratory of Optics and Photonic Devices, Center of Light Manipulation and Applications, School of Physics and Electronics, Shandong Normal University, Jinan 250358, ChinaRecent progress in nonlocal photonic modes within all-dielectric metasurfaces has established them as a promising alternative to traditional surface plasmon resonance technique for real-time monitoring of molecular interactions with high sensitivity. However, current implementations rely on optical spectroscopy to detect spectral changes, leading to expensive instrumentation. Here, we introduce an innovative approach that leverages the high-Q quasi-guided modes (QGMs) within all-dielectric nonlocal metasurfaces, utilizing angular interrogation as the detection mechanism. The pronounced spatial dispersion profile of the QGM allows for the detection of refractive index variations through the resonant angle of incidence. This method simplifies the detection process, using a simple continuous wave laser, thus eliminating the need for costly optical spectroscopy setups. Our experimental validation, conducted using a dimerized-hole photonic crystal slab, demonstrates effective characterization of the streptavidin–biotin binding interaction with remarkable sensitivity, detecting streptavidin with a threshold of less than 0.1 nM. This showcases the potential of our approach in molecular sensing applications.http://dx.doi.org/10.1063/5.0253249 |
| spellingShingle | Yujiao Bi Yuechun Shi Zhanghua Han Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactions APL Photonics |
| title | Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactions |
| title_full | Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactions |
| title_fullStr | Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactions |
| title_full_unstemmed | Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactions |
| title_short | Spatial-dispersioned nonlocal metasurfaces with angular interrogation: An efficient alternative to surface plasmon resonances for the characterization of bio-molecule interactions |
| title_sort | spatial dispersioned nonlocal metasurfaces with angular interrogation an efficient alternative to surface plasmon resonances for the characterization of bio molecule interactions |
| url | http://dx.doi.org/10.1063/5.0253249 |
| work_keys_str_mv | AT yujiaobi spatialdispersionednonlocalmetasurfaceswithangularinterrogationanefficientalternativetosurfaceplasmonresonancesforthecharacterizationofbiomoleculeinteractions AT yuechunshi spatialdispersionednonlocalmetasurfaceswithangularinterrogationanefficientalternativetosurfaceplasmonresonancesforthecharacterizationofbiomoleculeinteractions AT zhanghuahan spatialdispersionednonlocalmetasurfaceswithangularinterrogationanefficientalternativetosurfaceplasmonresonancesforthecharacterizationofbiomoleculeinteractions |